Biotinated probe containing a long-terminal repeat hybridized to a mouse colon tumor and normal tissue

Moira E. Royston, Leonard H. Augenlicht

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The cloned complementary DNA pMCT-1, which contains an intracisternal A particle long-terminal repeat, is more highly expressed in a mouse colon tumor than in the normal mouse colon. In situ hybridization of biotin-substituted pMCT-1 to fixed frozen sections shows that expression of pMCT-1 is seen throughout the tumor and is highly heterogeneous on a cellular basis, while expression is undetectable in any cell in the normal colonic mucosa.

Original languageEnglish (US)
Pages (from-to)1339-1341
Number of pages3
JournalScience
Volume222
Issue number4630
StatePublished - 1983

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Terminal Repeat Sequences
Colon
Frozen Sections
Biotin
In Situ Hybridization
Neoplasms
Mucous Membrane
Complementary DNA

ASJC Scopus subject areas

  • General

Cite this

Biotinated probe containing a long-terminal repeat hybridized to a mouse colon tumor and normal tissue. / Royston, Moira E.; Augenlicht, Leonard H.

In: Science, Vol. 222, No. 4630, 1983, p. 1339-1341.

Research output: Contribution to journalArticle

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