Biomarker-calibrated protein intake and physical function in the women's health initiative

Jeannette M. Beasley, Betsy C. Wertheim, Andrea Z. Lacroix, Ross L. Prentice, Marian L. Neuhouser, Lesley F. Tinker, Stephen Kritchevsky, James M. Shikany, Charles Eaton, Zhao Chen, Cynthia A. Thomson

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objectives To determine whether preservation of physical function with aging may be partially met through modification in dietary protein intake. Design Prospective cohort study. Setting Women's Health Initiative (WHI) Clinical Trials (CT) and Observational Study (OS) conducted at 40 clinical centers. Participants Women aged 50 to 79 (N = 134,961) with dietary data and one or more physical function measures. Measurements Physical function was assessed using the short-form RAND-36 at baseline and annually beginning in 2005 for all WHI participants and at closeout for CT participants (average ~7 years after baseline). In a subset of 5,346 participants, physical performance measures (grip strength, number of chair stands in 15 seconds, and timed 6-m walk) were assessed at baseline and Years 1, 3, and 6. Calibrated energy and protein intake were derived from regression equations using baseline food frequency questionnaire data collected on the entire cohort and doubly labeled water and 24-hour urinary nitrogen collected from a representative sample as reference measures. Associations between calibrated protein intake and each of the physical function measures were assessed using generalized estimating equations. Results Calibrated protein intake ranged from 6.6% to 22.3% energy. Higher calibrated protein intake at baseline was associated with higher self-reported physical function (quintile (Q)5, 85.6, 95% confidence interval (CI) = 81.9-87.5; Q1, 75.4, 95% CI = 73.2-78.5, Ptrend =.002) and a slower rate of functional decline (annualized change: Q5, -0.47, 95% CI = -0.63 to -0.39; Q1, -0.98, 95% CI = -1.18 to -0.75, Ptrend =.02). Women with higher calibrated protein intake also had greater grip strength at baseline (Q5, 24.7 kg, 95% CI = 24.3-25.2 kg; Q1, 24.1 kg, 95% CI = 23.6-24.5 kg, P trend =.04) and slower declines in grip strength (annualized change: Q5, -0.45 kg, 95% CI = -0.39 to -0.63 kg; Q1, -0.59 kg, 95% CI = -0.50 to -0.66 kg, Ptrend =.03). Women with higher calibrated protein intake also completed more chair stands at baseline (Q5, 7.11, 95% CI = 6.91-7.26; Q1, 6.61, 95% CI = 6.46-6.76, Ptrend =.002). Conclusion Higher calibrated protein intake is associated with better physical function and performance and slower rates of decline in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1863-1871
Number of pages9
JournalJournal of the American Geriatrics Society
Volume61
Issue number11
DOIs
StatePublished - Nov 2013

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Women's Health
Biomarkers
Confidence Intervals
Proteins
Hand Strength
Clinical Trials
Dietary Proteins
Energy Intake
Observational Studies
Cohort Studies
Nitrogen
Prospective Studies
Food
Water

Keywords

  • dietary protein intake
  • grip strength
  • physical function
  • physical performance

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Beasley, J. M., Wertheim, B. C., Lacroix, A. Z., Prentice, R. L., Neuhouser, M. L., Tinker, L. F., ... Thomson, C. A. (2013). Biomarker-calibrated protein intake and physical function in the women's health initiative. Journal of the American Geriatrics Society, 61(11), 1863-1871. https://doi.org/10.1111/jgs.12503

Biomarker-calibrated protein intake and physical function in the women's health initiative. / Beasley, Jeannette M.; Wertheim, Betsy C.; Lacroix, Andrea Z.; Prentice, Ross L.; Neuhouser, Marian L.; Tinker, Lesley F.; Kritchevsky, Stephen; Shikany, James M.; Eaton, Charles; Chen, Zhao; Thomson, Cynthia A.

In: Journal of the American Geriatrics Society, Vol. 61, No. 11, 11.2013, p. 1863-1871.

Research output: Contribution to journalArticle

Beasley, JM, Wertheim, BC, Lacroix, AZ, Prentice, RL, Neuhouser, ML, Tinker, LF, Kritchevsky, S, Shikany, JM, Eaton, C, Chen, Z & Thomson, CA 2013, 'Biomarker-calibrated protein intake and physical function in the women's health initiative', Journal of the American Geriatrics Society, vol. 61, no. 11, pp. 1863-1871. https://doi.org/10.1111/jgs.12503
Beasley JM, Wertheim BC, Lacroix AZ, Prentice RL, Neuhouser ML, Tinker LF et al. Biomarker-calibrated protein intake and physical function in the women's health initiative. Journal of the American Geriatrics Society. 2013 Nov;61(11):1863-1871. https://doi.org/10.1111/jgs.12503
Beasley, Jeannette M. ; Wertheim, Betsy C. ; Lacroix, Andrea Z. ; Prentice, Ross L. ; Neuhouser, Marian L. ; Tinker, Lesley F. ; Kritchevsky, Stephen ; Shikany, James M. ; Eaton, Charles ; Chen, Zhao ; Thomson, Cynthia A. / Biomarker-calibrated protein intake and physical function in the women's health initiative. In: Journal of the American Geriatrics Society. 2013 ; Vol. 61, No. 11. pp. 1863-1871.
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abstract = "Objectives To determine whether preservation of physical function with aging may be partially met through modification in dietary protein intake. Design Prospective cohort study. Setting Women's Health Initiative (WHI) Clinical Trials (CT) and Observational Study (OS) conducted at 40 clinical centers. Participants Women aged 50 to 79 (N = 134,961) with dietary data and one or more physical function measures. Measurements Physical function was assessed using the short-form RAND-36 at baseline and annually beginning in 2005 for all WHI participants and at closeout for CT participants (average ~7 years after baseline). In a subset of 5,346 participants, physical performance measures (grip strength, number of chair stands in 15 seconds, and timed 6-m walk) were assessed at baseline and Years 1, 3, and 6. Calibrated energy and protein intake were derived from regression equations using baseline food frequency questionnaire data collected on the entire cohort and doubly labeled water and 24-hour urinary nitrogen collected from a representative sample as reference measures. Associations between calibrated protein intake and each of the physical function measures were assessed using generalized estimating equations. Results Calibrated protein intake ranged from 6.6{\%} to 22.3{\%} energy. Higher calibrated protein intake at baseline was associated with higher self-reported physical function (quintile (Q)5, 85.6, 95{\%} confidence interval (CI) = 81.9-87.5; Q1, 75.4, 95{\%} CI = 73.2-78.5, Ptrend =.002) and a slower rate of functional decline (annualized change: Q5, -0.47, 95{\%} CI = -0.63 to -0.39; Q1, -0.98, 95{\%} CI = -1.18 to -0.75, Ptrend =.02). Women with higher calibrated protein intake also had greater grip strength at baseline (Q5, 24.7 kg, 95{\%} CI = 24.3-25.2 kg; Q1, 24.1 kg, 95{\%} CI = 23.6-24.5 kg, P trend =.04) and slower declines in grip strength (annualized change: Q5, -0.45 kg, 95{\%} CI = -0.39 to -0.63 kg; Q1, -0.59 kg, 95{\%} CI = -0.50 to -0.66 kg, Ptrend =.03). Women with higher calibrated protein intake also completed more chair stands at baseline (Q5, 7.11, 95{\%} CI = 6.91-7.26; Q1, 6.61, 95{\%} CI = 6.46-6.76, Ptrend =.002). Conclusion Higher calibrated protein intake is associated with better physical function and performance and slower rates of decline in postmenopausal women.",
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author = "Beasley, {Jeannette M.} and Wertheim, {Betsy C.} and Lacroix, {Andrea Z.} and Prentice, {Ross L.} and Neuhouser, {Marian L.} and Tinker, {Lesley F.} and Stephen Kritchevsky and Shikany, {James M.} and Charles Eaton and Zhao Chen and Thomson, {Cynthia A.}",
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AU - Beasley, Jeannette M.

AU - Wertheim, Betsy C.

AU - Lacroix, Andrea Z.

AU - Prentice, Ross L.

AU - Neuhouser, Marian L.

AU - Tinker, Lesley F.

AU - Kritchevsky, Stephen

AU - Shikany, James M.

AU - Eaton, Charles

AU - Chen, Zhao

AU - Thomson, Cynthia A.

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N2 - Objectives To determine whether preservation of physical function with aging may be partially met through modification in dietary protein intake. Design Prospective cohort study. Setting Women's Health Initiative (WHI) Clinical Trials (CT) and Observational Study (OS) conducted at 40 clinical centers. Participants Women aged 50 to 79 (N = 134,961) with dietary data and one or more physical function measures. Measurements Physical function was assessed using the short-form RAND-36 at baseline and annually beginning in 2005 for all WHI participants and at closeout for CT participants (average ~7 years after baseline). In a subset of 5,346 participants, physical performance measures (grip strength, number of chair stands in 15 seconds, and timed 6-m walk) were assessed at baseline and Years 1, 3, and 6. Calibrated energy and protein intake were derived from regression equations using baseline food frequency questionnaire data collected on the entire cohort and doubly labeled water and 24-hour urinary nitrogen collected from a representative sample as reference measures. Associations between calibrated protein intake and each of the physical function measures were assessed using generalized estimating equations. Results Calibrated protein intake ranged from 6.6% to 22.3% energy. Higher calibrated protein intake at baseline was associated with higher self-reported physical function (quintile (Q)5, 85.6, 95% confidence interval (CI) = 81.9-87.5; Q1, 75.4, 95% CI = 73.2-78.5, Ptrend =.002) and a slower rate of functional decline (annualized change: Q5, -0.47, 95% CI = -0.63 to -0.39; Q1, -0.98, 95% CI = -1.18 to -0.75, Ptrend =.02). Women with higher calibrated protein intake also had greater grip strength at baseline (Q5, 24.7 kg, 95% CI = 24.3-25.2 kg; Q1, 24.1 kg, 95% CI = 23.6-24.5 kg, P trend =.04) and slower declines in grip strength (annualized change: Q5, -0.45 kg, 95% CI = -0.39 to -0.63 kg; Q1, -0.59 kg, 95% CI = -0.50 to -0.66 kg, Ptrend =.03). Women with higher calibrated protein intake also completed more chair stands at baseline (Q5, 7.11, 95% CI = 6.91-7.26; Q1, 6.61, 95% CI = 6.46-6.76, Ptrend =.002). Conclusion Higher calibrated protein intake is associated with better physical function and performance and slower rates of decline in postmenopausal women.

AB - Objectives To determine whether preservation of physical function with aging may be partially met through modification in dietary protein intake. Design Prospective cohort study. Setting Women's Health Initiative (WHI) Clinical Trials (CT) and Observational Study (OS) conducted at 40 clinical centers. Participants Women aged 50 to 79 (N = 134,961) with dietary data and one or more physical function measures. Measurements Physical function was assessed using the short-form RAND-36 at baseline and annually beginning in 2005 for all WHI participants and at closeout for CT participants (average ~7 years after baseline). In a subset of 5,346 participants, physical performance measures (grip strength, number of chair stands in 15 seconds, and timed 6-m walk) were assessed at baseline and Years 1, 3, and 6. Calibrated energy and protein intake were derived from regression equations using baseline food frequency questionnaire data collected on the entire cohort and doubly labeled water and 24-hour urinary nitrogen collected from a representative sample as reference measures. Associations between calibrated protein intake and each of the physical function measures were assessed using generalized estimating equations. Results Calibrated protein intake ranged from 6.6% to 22.3% energy. Higher calibrated protein intake at baseline was associated with higher self-reported physical function (quintile (Q)5, 85.6, 95% confidence interval (CI) = 81.9-87.5; Q1, 75.4, 95% CI = 73.2-78.5, Ptrend =.002) and a slower rate of functional decline (annualized change: Q5, -0.47, 95% CI = -0.63 to -0.39; Q1, -0.98, 95% CI = -1.18 to -0.75, Ptrend =.02). Women with higher calibrated protein intake also had greater grip strength at baseline (Q5, 24.7 kg, 95% CI = 24.3-25.2 kg; Q1, 24.1 kg, 95% CI = 23.6-24.5 kg, P trend =.04) and slower declines in grip strength (annualized change: Q5, -0.45 kg, 95% CI = -0.39 to -0.63 kg; Q1, -0.59 kg, 95% CI = -0.50 to -0.66 kg, Ptrend =.03). Women with higher calibrated protein intake also completed more chair stands at baseline (Q5, 7.11, 95% CI = 6.91-7.26; Q1, 6.61, 95% CI = 6.46-6.76, Ptrend =.002). Conclusion Higher calibrated protein intake is associated with better physical function and performance and slower rates of decline in postmenopausal women.

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KW - grip strength

KW - physical function

KW - physical performance

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