Bilirubin metabolism: Applied physiology

Xia Wang, Jayanta Roy Chowdhury, Namita Roy Chowdhury

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Bilirubin is the breakdown product of the haem moiety of haemoglobin and other haemoproteins. Because of internal hydrogen bonding, bilirubin is water-insoluble and requires enzyme-mediated glucuronidation in the liver for biliary excretion. In normal circumstances, plasma bilirubin is mostly unconjugated and is tightly bound to circulating albumin. It is taken up by hepatocytes by facilitated diffusion, stored in hepatocytes bound to glutathione-S-transferases and conjugated to glucuronides by microsomal UGT1A1. Bilirubin glucuronides are actively transported into the bile canaliculi by the ATP-utilizing pump MRP2. Bilirubin is degraded in the intestine by bacteria into urobilinogens, which are partly excreted in the urine. Increased production, reduced uptake and low glucuronidation capacity can increase plasma unconjugated bilirubin levels. In cases of inherited or acquired deficiencies of bilirubin storage or excretion, both conjugated and unconjugated bilirubin accumulate in the plasma. Conjugated bilirubin is less tightly bound to albumin and is excreted in the urine. The capacities of the various steps of bilirubin throughput are finely balanced, and the expression of the gene products mediating these steps is coordinated by nuclear receptors.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalCurrent Paediatrics
Volume16
Issue number1
DOIs
StatePublished - Feb 2006

Keywords

  • ABCC2
  • Bilirubin
  • Bilirubin glucuronides
  • UGT1A1

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Bilirubin metabolism: Applied physiology'. Together they form a unique fingerprint.

  • Cite this