BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid

Thomas Fricke, Cindy Buffone, Silvana Opp, Jose Valle-Casuso, Felipe Diaz-Griffero

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background: The recently discovered small-molecule BI-2 potently blocks HIV-1 infection. BI-2 binds to the N-terminal domain of HIV-1 capsid. BI-2 utilizes the same capsid pocket used by the small molecule PF74. Although both drugs bind to the same pocket, it has been proposed that BI-2 uses a different mechanism to block HIV-1 infection when compared to PF74. Findings: This work demonstrates that BI-2 destabilizes the HIV-1 core during infection, and prevents the binding of the cellular factor CPSF6 to the HIV-1 core. Conclusions: Overall this short-form paper suggests that BI-2 is using a similar mechanism to the one used by PF74 to block HIV-1 infection.

Original languageEnglish (US)
Article number120
JournalRetrovirology
Volume11
Issue number1
DOIs
StatePublished - Dec 11 2014

Keywords

  • BI-2
  • CPSF6
  • Capsid
  • HIV-1
  • PF74
  • Stability
  • Uncoating

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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