Bensal HP Attenuates the Inflammatory Response in Hair Shaving Associated Dermatitis

Anjana Ray, Breanne Mordorski, Angelo Landriscina, Jamie Rosen, Joshua D. Nosanchuk, Adam Friedman

Research output: Contribution to journalArticle

Abstract

Shaving is an ubiquitous practice, and cutaneous irritation and inflammation are common sequelae, which may be worsened by underlying skin conditions or poor hair removal techniques. Moisturizing shaving creams and aftershaves are available to help maintain or restore the epidermal barrier; however, many continue to suffer from post-shave redness, itching, and pain. To reduce post-shave inflammation, some products have included botanical and other natural ingredients, which are often favored by consumers. We evaluated Bensal HP, an ointment containing 3% oak bark extract, 3% salicylic acid, and 6% benzoic acid, which has documented anti-inflammatory and antimicrobial properties, in a murine model of shave irritation to determine whether it would be useful in this clinical setting. Shaving dermatitis was simulated using a depilatory agent and electric clippers, and the shaved area was photographed and treated with Bensal HP daily for four days. Compared to untreated controls, mice treated with Bensal HP experienced a visible reduction in skin irritation and inflammation. These findings were mirrored on histology, as Bensal HP-treated areas demonstrated increased epidermal integrity and decreased dermal inflammatory infiltrate compared to untreated skin. Using immunohistochemistry, fewer neutrophils and macrophages were noted, and cytokine analysis also revealed decreased IL-6 in Bensal HP-treated skin at 24 and 96 hours after shaving. These results highlight the potential of Bensal HP as an anti-inflammatory treatment for shave irritation. Given the product's application against a variety of inflammatory and infectious skin disorders, its use against shave irritation may also improve comorbid skin conditions, such as pseudofolliculitis barbae.

J Drugs Dermatol. 2016;15(7):836-840.

Original languageEnglish (US)
Pages (from-to)836-840
Number of pages5
JournalJournal of drugs in dermatology : JDD
Volume15
Issue number7
StatePublished - Jul 1 2016

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Dermatitis
Hair
Skin
Inflammation
Anti-Inflammatory Agents
Hair Removal
Benzoic Acid
Salicylic Acid
Pruritus
Ointments
Interleukin-6
Histology
Neutrophils
Immunohistochemistry
Macrophages
Cytokines
Pain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)
  • Dermatology

Cite this

Ray, A., Mordorski, B., Landriscina, A., Rosen, J., Nosanchuk, J. D., & Friedman, A. (2016). Bensal HP Attenuates the Inflammatory Response in Hair Shaving Associated Dermatitis. Journal of drugs in dermatology : JDD, 15(7), 836-840.

Bensal HP Attenuates the Inflammatory Response in Hair Shaving Associated Dermatitis. / Ray, Anjana; Mordorski, Breanne; Landriscina, Angelo; Rosen, Jamie; Nosanchuk, Joshua D.; Friedman, Adam.

In: Journal of drugs in dermatology : JDD, Vol. 15, No. 7, 01.07.2016, p. 836-840.

Research output: Contribution to journalArticle

Ray, A, Mordorski, B, Landriscina, A, Rosen, J, Nosanchuk, JD & Friedman, A 2016, 'Bensal HP Attenuates the Inflammatory Response in Hair Shaving Associated Dermatitis', Journal of drugs in dermatology : JDD, vol. 15, no. 7, pp. 836-840.
Ray, Anjana ; Mordorski, Breanne ; Landriscina, Angelo ; Rosen, Jamie ; Nosanchuk, Joshua D. ; Friedman, Adam. / Bensal HP Attenuates the Inflammatory Response in Hair Shaving Associated Dermatitis. In: Journal of drugs in dermatology : JDD. 2016 ; Vol. 15, No. 7. pp. 836-840.
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