Benign parotid hypertrophy in +HIV patients: Limited late failures after external radiation

Jonathan J. Beitler, Richard V. Smith, Allan L. Brook, Morris Edelman, Anand Sharma, Maria Serrano, Carl E. Silver, Lawrence W. Davis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: Although 8-10 Gy of external radiation therapy for +HIV associated parotid hypertrophy has achieved high response rates, the responses were transient with only 1/12 of patients retaining cosmetic control at median follow-up procedures of 9.5 months. Retreatment for failures after 8-10 Gy has also been unsatisfactory. Having shown that 24 Gy of external radiation therapy for benign parotid hypertrophy produced more durable cosmetic control than 8-10 Gy, we now report on longer follow-up periods on a group of patients receiving 24 Gy.Materials and Methods: Twenty +HIV patients with clinical and radiographic evidence of lymphoepithelial lesions of the parotid were treated with 24 Gy of external radiation therapy using daily 1.5 Gy fractions; parallel opposed technique and 6 MV photons were used in 19 patients, and unilateral electron treatment was performed for one patient.Results: With a mean follow-up period of 24 months, the cosmetic control appears durable. We have had no late failures past 24 months. Two patients have complained of modest xerostomia. There was no correlation with size of the cyst and eventual cosmetic result.Conclusions: Twenty-four Gy produces durable parotid control for HIV associated lymphoepithelial lesions of the parotid glands in +HIV patients. Failures after 2 years are uncommon and the side effects have been tolerable. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)451-455
Number of pages5
JournalInternational Journal of Radiation Oncology Biology Physics
Volume45
Issue number2
DOIs
StatePublished - Sep 1 1999

Fingerprint

human immunodeficiency virus
Hypertrophy
HIV
Radiation
Radiation Dosage
Cosmetics
radiation
radiation therapy
Radiotherapy
lesions
salivary glands
Xerostomia
cysts
Retreatment
Parotid Gland
transient response
retaining
Photons
Cysts
Electrons

Keywords

  • Benign lymphoepithelial cysts
  • Benign parotid hypertrophy
  • HIV-associated lymphoepithelial cysts
  • Lymphoepithelial cysts
  • Parotid gland hypertrophy
  • Parotid hypertrophy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Benign parotid hypertrophy in +HIV patients : Limited late failures after external radiation. / Beitler, Jonathan J.; Smith, Richard V.; Brook, Allan L.; Edelman, Morris; Sharma, Anand; Serrano, Maria; Silver, Carl E.; Davis, Lawrence W.

In: International Journal of Radiation Oncology Biology Physics, Vol. 45, No. 2, 01.09.1999, p. 451-455.

Research output: Contribution to journalArticle

Beitler, Jonathan J. ; Smith, Richard V. ; Brook, Allan L. ; Edelman, Morris ; Sharma, Anand ; Serrano, Maria ; Silver, Carl E. ; Davis, Lawrence W. / Benign parotid hypertrophy in +HIV patients : Limited late failures after external radiation. In: International Journal of Radiation Oncology Biology Physics. 1999 ; Vol. 45, No. 2. pp. 451-455.
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