Benefits and costs of animal virulence for microbes

Arturo Casadevall, Liise-anne Pirofski

Research output: Contribution to journalShort survey

Abstract

This essay is written from the vantage point of the microbial world. While the focus of much thought in the microbial pathogenesis and infectious diseases fields has been on the impact of host-microbe interaction on the host, here we ask questions about what happens to the microbe. What are the costs and benefits for microbes of having the capacity for virulence? Our exploration of this topic leads us to conclude that virulence confers very few benefits for microbes, unless disease is necessary for microbial survival through host-to-host spread. In fact, the capacity for virulence is often fraught with risk for microbes, including host dependence and the threat of extinction. The costs of virulence may explain why, relative to their enormous numbers in nature, very few microbes are actually associated with human and animal disease.

Original languageEnglish (US)
Article numbere00863-19
JournalmBio
Volume10
Issue number3
DOIs
StatePublished - May 1 2019

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Cost-Benefit Analysis
Virulence
Animal Diseases
Communicable Diseases
Costs and Cost Analysis
Survival

Keywords

  • Benefits
  • Costs
  • Microbial
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Virology

Cite this

Benefits and costs of animal virulence for microbes. / Casadevall, Arturo; Pirofski, Liise-anne.

In: mBio, Vol. 10, No. 3, e00863-19, 01.05.2019.

Research output: Contribution to journalShort survey

Casadevall, Arturo ; Pirofski, Liise-anne. / Benefits and costs of animal virulence for microbes. In: mBio. 2019 ; Vol. 10, No. 3.
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