Behavioural response to m-chlorophenylpiperazine and clonidine in trichotillomania

D. J. Stein, Eric Hollander, C. De Carcia, L. Cohen, D. Simeon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Administration of m-chlorophenyl-piperazine (m-CPP), a partial serotonin agonist, may lead to acute exacerbation of symptoms of obsessive-compulsive disorder (OCD), whereas administration of the alpha-2 adrenergic agonist, clonidine, may be followed by an acute decrease in symptoms. We studied behavioural response of 11 patients with trichotillomania, a disorder possibly related to OCD, to these agents and to placebo. No significant drug effects on specific trichotillomania symptoms were found. Patients experienced more of a 'high' feeling on m-CPP than on clonidine or placebo, a finding similar to that seen in patients with impulsive personality disorders.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalJournal of Serotonin Research
Volume4
Issue number1
StatePublished - 1997
Externally publishedYes

Fingerprint

Trichotillomania
Clonidine
Obsessive-Compulsive Disorder
Adrenergic alpha-2 Receptor Agonists
Placebos
Serotonin Receptor Agonists
Personality Disorders
Emotions
Pharmaceutical Preparations
1-(3-chlorophenyl)piperazine
piperazine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

Cite this

Behavioural response to m-chlorophenylpiperazine and clonidine in trichotillomania. / Stein, D. J.; Hollander, Eric; De Carcia, C.; Cohen, L.; Simeon, D.

In: Journal of Serotonin Research, Vol. 4, No. 1, 1997, p. 11-15.

Research output: Contribution to journalArticle

Stein, D. J. ; Hollander, Eric ; De Carcia, C. ; Cohen, L. ; Simeon, D. / Behavioural response to m-chlorophenylpiperazine and clonidine in trichotillomania. In: Journal of Serotonin Research. 1997 ; Vol. 4, No. 1. pp. 11-15.
@article{39ec9366492a4c5db2126ccc280c89b2,
title = "Behavioural response to m-chlorophenylpiperazine and clonidine in trichotillomania",
abstract = "Administration of m-chlorophenyl-piperazine (m-CPP), a partial serotonin agonist, may lead to acute exacerbation of symptoms of obsessive-compulsive disorder (OCD), whereas administration of the alpha-2 adrenergic agonist, clonidine, may be followed by an acute decrease in symptoms. We studied behavioural response of 11 patients with trichotillomania, a disorder possibly related to OCD, to these agents and to placebo. No significant drug effects on specific trichotillomania symptoms were found. Patients experienced more of a 'high' feeling on m-CPP than on clonidine or placebo, a finding similar to that seen in patients with impulsive personality disorders.",
author = "Stein, {D. J.} and Eric Hollander and {De Carcia}, C. and L. Cohen and D. Simeon",
year = "1997",
language = "English (US)",
volume = "4",
pages = "11--15",
journal = "Journal of Serotonin Research",
issn = "1350-7702",
publisher = "Koninklijke Nederlandse Maatschappij voor Diergeneeskunde",
number = "1",

}

TY - JOUR

T1 - Behavioural response to m-chlorophenylpiperazine and clonidine in trichotillomania

AU - Stein, D. J.

AU - Hollander, Eric

AU - De Carcia, C.

AU - Cohen, L.

AU - Simeon, D.

PY - 1997

Y1 - 1997

N2 - Administration of m-chlorophenyl-piperazine (m-CPP), a partial serotonin agonist, may lead to acute exacerbation of symptoms of obsessive-compulsive disorder (OCD), whereas administration of the alpha-2 adrenergic agonist, clonidine, may be followed by an acute decrease in symptoms. We studied behavioural response of 11 patients with trichotillomania, a disorder possibly related to OCD, to these agents and to placebo. No significant drug effects on specific trichotillomania symptoms were found. Patients experienced more of a 'high' feeling on m-CPP than on clonidine or placebo, a finding similar to that seen in patients with impulsive personality disorders.

AB - Administration of m-chlorophenyl-piperazine (m-CPP), a partial serotonin agonist, may lead to acute exacerbation of symptoms of obsessive-compulsive disorder (OCD), whereas administration of the alpha-2 adrenergic agonist, clonidine, may be followed by an acute decrease in symptoms. We studied behavioural response of 11 patients with trichotillomania, a disorder possibly related to OCD, to these agents and to placebo. No significant drug effects on specific trichotillomania symptoms were found. Patients experienced more of a 'high' feeling on m-CPP than on clonidine or placebo, a finding similar to that seen in patients with impulsive personality disorders.

UR - http://www.scopus.com/inward/record.url?scp=0030839379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030839379&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030839379

VL - 4

SP - 11

EP - 15

JO - Journal of Serotonin Research

JF - Journal of Serotonin Research

SN - 1350-7702

IS - 1

ER -