Basiliximab induction improves the outcome of renal transplants in children and adolescents

A. Swiatecka-Urban, C. Garcia, D. Feuerstein, S. Suzuki, P. Devarajan, R. Schechner, S. Greenstein, V. Tellis, F. Kaskel

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Thirty-two children and adolescents received their renal transplant at the Montefiore Medical Center, in New York, between October 1996 and May 2000. Twenty-four patients received basiliximab, in addition to tacrolimus and steroids (basiliximab group). The remaining eight patients received only tacrolimus and steroids (non-basiliximab group). The 1-year patient survival rate was 100% in both groups. The 1-year graft survival rate was 87.5% for the basiliximab group and 75% for the non-basiliximab group (P=0.45). The rates of acute rejection in the basiliximab and non-basiliximab groups were 26% and 43%, respectively (P=0.36). However, in recipients with ≤3 HLA mismatches, the rate of acute rejection was zero in the basiliximab group, and 40% in the non-basiliximab group (P=0.04). The beneficial effect occurred despite the fact that tacrolimus was maintained at below the target levels. There were no adverse events directly attributable to the administration of basiliximab. There were no cases of opportunistic infections or post-transplant lymphoproliferative disease. In summary, addition of basiliximab to tacrolimus and prednisone significantly decreased the rate of acute rejection in well-matched patients. Moreover, this effect was manifest at lower, and therefore less toxic, tacrolimus levels.

Original languageEnglish (US)
Pages (from-to)693-696
Number of pages4
JournalPediatric Nephrology
Volume16
Issue number9
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Basiliximab
  • Post-transplant diabetes mellitus
  • Post-transplant lymphoproliferative disease
  • Tacrolimus
  • Target levels

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Swiatecka-Urban, A., Garcia, C., Feuerstein, D., Suzuki, S., Devarajan, P., Schechner, R., Greenstein, S., Tellis, V., & Kaskel, F. (2001). Basiliximab induction improves the outcome of renal transplants in children and adolescents. Pediatric Nephrology, 16(9), 693-696. https://doi.org/10.1007/s004670100642