Basal serum follicle stimulating hormone (FSH) and estradiol levels as predictors of pregnancy in unstimulated donor insemination cycles

Barry R. Witt, David H. Barad, Patricia Barg, Brian L. Cohen, Steven R. Lindheim, Lynn Testaiuti, Hussein K. Amin

Research output: Contribution to journalArticle

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Abstract

Purpose: The purpose of this study was to evaluate the utility of basal serum follicle stimulating hormone and estradiol levels in predicting pregnancy in women undergoing artificial insemination with donor sperm for severe male factor infertility. Method: A retrospective chart review of 48 women who had at least 2 cycles of artificial insemination with donor sperm and who had undergone testing for basal serum follicle stimulating hormone and estradiol levels prior to or during therapy. Results: There was no difference in age or mean basal serum follicle stimulating hormone between women who conceived (clinical pregnancy) and those who did not. Women who conceived had significantly lower mean serum basal estradiol levels (P = 0.02) and significantly fewer numbers of treatment cycles (P = 0.041). The highest pregnancy rate was among those women with normal basal serum follicle stimulating hormone and estradiol levels. Receiver operating characteristic curve analysis revealed basal serum estradiol to be a more reliable predictor of pregnancy than follicle stimulating hormone. Conclusions: Basal serum follicle stimulating hormone and estradiol levels may be useful in predicting success with artificial insemination with donor sperm. It may be useful to obtain basal serum follicle stimulating hormone and estradiol prior to initiating artificial insemination with donor sperm.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Volume12
Issue number3
DOIs
StatePublished - Mar 1995

Fingerprint

Insemination
Follicle Stimulating Hormone
Estradiol
Tissue Donors
Pregnancy
Serum
Spermatozoa
Male Infertility
Pregnancy Rate
ROC Curve
Therapeutics

Keywords

  • donor insemination
  • estradiol
  • follicle stimulating hormone
  • pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Genetics
  • Developmental Biology

Cite this

Basal serum follicle stimulating hormone (FSH) and estradiol levels as predictors of pregnancy in unstimulated donor insemination cycles. / Witt, Barry R.; Barad, David H.; Barg, Patricia; Cohen, Brian L.; Lindheim, Steven R.; Testaiuti, Lynn; Amin, Hussein K.

In: Journal of Assisted Reproduction and Genetics, Vol. 12, No. 3, 03.1995, p. 157-160.

Research output: Contribution to journalArticle

Witt, Barry R. ; Barad, David H. ; Barg, Patricia ; Cohen, Brian L. ; Lindheim, Steven R. ; Testaiuti, Lynn ; Amin, Hussein K. / Basal serum follicle stimulating hormone (FSH) and estradiol levels as predictors of pregnancy in unstimulated donor insemination cycles. In: Journal of Assisted Reproduction and Genetics. 1995 ; Vol. 12, No. 3. pp. 157-160.
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