Barriers to the successful treatment of liver disease by hepatocyte transplantation

Kyle A. Soltys, Alejandro Soto-Gutiérrez, Masaki Nagaya, Kevin M. Baskin, Melvin Deutsch, Ryotaro Ito, Benjamin L. Shneider, Robert Squires, Jerry Vockley, Chandan Guha, Jayanta Roy-Chowdhury, Stephen C. Strom, Jeffrey L. Platt, Ira J. Fox

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Treatment of patients with liver disease by hepatocyte transplantation has expanded dramatically over the last decade, especially for treatment of patients with liver-based metabolic disorders. While much progress has been made, full realization of its potential has not been reached. Treatment of acute liver failure has been hampered by a number of factors, but the efficacy of hepatocyte transplantation in treating this entity could be better determined through a multi-institutional trial using a uniform and standardized treatment strategy. The barriers to treating chronic liver failure resulting from cirrhosis are more extensive. Novel strategies are being developed to safely precondition patients with liver-directed radiation therapy in order to enhance donor hepatocyte survival, long-term engraftment and improve treatment of patients with life-threatening liver-based genetic deficiencies. This work could soon be translated to the clinic. Once hepatocyte transplantation has been shown to effectively replace organ transplantation for a portion of patients with liver failure and life-threatening liver metabolic diseases, it is likely that multiple novel sources of donor hepatocytes will be developed, making cell therapy available and effective for a broad population of patients with liver disorders.

Original languageEnglish (US)
Pages (from-to)769-774
Number of pages6
JournalJournal of Hepatology
Volume53
Issue number4
DOIs
StatePublished - Oct 2010

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Liver Diseases
Hepatocytes
Transplantation
Liver
Therapeutics
Tissue Donors
End Stage Liver Disease
Acute Liver Failure
Metabolic Diseases
Liver Failure
Organ Transplantation
Cell- and Tissue-Based Therapy
Fibrosis
Radiotherapy
Population

Keywords

  • Hepatocyte transplantation

ASJC Scopus subject areas

  • Hepatology

Cite this

Soltys, K. A., Soto-Gutiérrez, A., Nagaya, M., Baskin, K. M., Deutsch, M., Ito, R., ... Fox, I. J. (2010). Barriers to the successful treatment of liver disease by hepatocyte transplantation. Journal of Hepatology, 53(4), 769-774. https://doi.org/10.1016/j.jhep.2010.05.010

Barriers to the successful treatment of liver disease by hepatocyte transplantation. / Soltys, Kyle A.; Soto-Gutiérrez, Alejandro; Nagaya, Masaki; Baskin, Kevin M.; Deutsch, Melvin; Ito, Ryotaro; Shneider, Benjamin L.; Squires, Robert; Vockley, Jerry; Guha, Chandan; Roy-Chowdhury, Jayanta; Strom, Stephen C.; Platt, Jeffrey L.; Fox, Ira J.

In: Journal of Hepatology, Vol. 53, No. 4, 10.2010, p. 769-774.

Research output: Contribution to journalArticle

Soltys, KA, Soto-Gutiérrez, A, Nagaya, M, Baskin, KM, Deutsch, M, Ito, R, Shneider, BL, Squires, R, Vockley, J, Guha, C, Roy-Chowdhury, J, Strom, SC, Platt, JL & Fox, IJ 2010, 'Barriers to the successful treatment of liver disease by hepatocyte transplantation', Journal of Hepatology, vol. 53, no. 4, pp. 769-774. https://doi.org/10.1016/j.jhep.2010.05.010
Soltys KA, Soto-Gutiérrez A, Nagaya M, Baskin KM, Deutsch M, Ito R et al. Barriers to the successful treatment of liver disease by hepatocyte transplantation. Journal of Hepatology. 2010 Oct;53(4):769-774. https://doi.org/10.1016/j.jhep.2010.05.010
Soltys, Kyle A. ; Soto-Gutiérrez, Alejandro ; Nagaya, Masaki ; Baskin, Kevin M. ; Deutsch, Melvin ; Ito, Ryotaro ; Shneider, Benjamin L. ; Squires, Robert ; Vockley, Jerry ; Guha, Chandan ; Roy-Chowdhury, Jayanta ; Strom, Stephen C. ; Platt, Jeffrey L. ; Fox, Ira J. / Barriers to the successful treatment of liver disease by hepatocyte transplantation. In: Journal of Hepatology. 2010 ; Vol. 53, No. 4. pp. 769-774.
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