Bacterial vaccine vectors and bacillus calmette-guérin

Jeffrey D. Cirillo, C. Kendall Stover, Barry R. Bloom, William R. Jacobs, Raúl G. Barletta

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Recent advances in biotechnology now allow a more modern approach to the development of vaccines, particularly that of recombinant vaccines, Bacterial vaccine vectors have the advantage over viral vectors in that the former have the ability to express a greater number of antigens in different forms. Although no recombinant bacterial vaccines are currently in use, bacillus Calmette-Guérin (BCG), Salmonella species, and Escherichia coli are being developed as vaccine vectors. We review plasmid systems and mutant strains developed for the expression of foreign antigens, with particular emphasis on those developed for BCG. We describe the development of antigen expression systems as well as the immune response elicited by recombinant BCG vaccine strains to bacterial and human immunodeficiency virus (HIV) antigens. A modified recombinant BCG carrier with selection for the stable maintenance of rDNA is proposed.

Original languageEnglish (US)
Pages (from-to)1001-1009
Number of pages9
JournalClinical Infectious Diseases
Volume20
Issue number4
DOIs
StatePublished - Apr 1995

Fingerprint

Bacterial Vaccines
Bacillus
Antigens
Synthetic Vaccines
Vaccines
BCG Vaccine
Biotechnology
Ribosomal DNA
Salmonella
Plasmids
Maintenance
HIV
Escherichia coli

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Cirillo, J. D., Stover, C. K., Bloom, B. R., Jacobs, W. R., & Barletta, R. G. (1995). Bacterial vaccine vectors and bacillus calmette-guérin. Clinical Infectious Diseases, 20(4), 1001-1009. https://doi.org/10.1093/clinids/20.4.1001

Bacterial vaccine vectors and bacillus calmette-guérin. / Cirillo, Jeffrey D.; Stover, C. Kendall; Bloom, Barry R.; Jacobs, William R.; Barletta, Raúl G.

In: Clinical Infectious Diseases, Vol. 20, No. 4, 04.1995, p. 1001-1009.

Research output: Contribution to journalArticle

Cirillo, JD, Stover, CK, Bloom, BR, Jacobs, WR & Barletta, RG 1995, 'Bacterial vaccine vectors and bacillus calmette-guérin', Clinical Infectious Diseases, vol. 20, no. 4, pp. 1001-1009. https://doi.org/10.1093/clinids/20.4.1001
Cirillo, Jeffrey D. ; Stover, C. Kendall ; Bloom, Barry R. ; Jacobs, William R. ; Barletta, Raúl G. / Bacterial vaccine vectors and bacillus calmette-guérin. In: Clinical Infectious Diseases. 1995 ; Vol. 20, No. 4. pp. 1001-1009.
@article{acb9a9a7c5694477a348effc52d93a4b,
title = "Bacterial vaccine vectors and bacillus calmette-gu{\'e}rin",
abstract = "Recent advances in biotechnology now allow a more modern approach to the development of vaccines, particularly that of recombinant vaccines, Bacterial vaccine vectors have the advantage over viral vectors in that the former have the ability to express a greater number of antigens in different forms. Although no recombinant bacterial vaccines are currently in use, bacillus Calmette-Gu{\'e}rin (BCG), Salmonella species, and Escherichia coli are being developed as vaccine vectors. We review plasmid systems and mutant strains developed for the expression of foreign antigens, with particular emphasis on those developed for BCG. We describe the development of antigen expression systems as well as the immune response elicited by recombinant BCG vaccine strains to bacterial and human immunodeficiency virus (HIV) antigens. A modified recombinant BCG carrier with selection for the stable maintenance of rDNA is proposed.",
author = "Cirillo, {Jeffrey D.} and Stover, {C. Kendall} and Bloom, {Barry R.} and Jacobs, {William R.} and Barletta, {Ra{\'u}l G.}",
year = "1995",
month = "4",
doi = "10.1093/clinids/20.4.1001",
language = "English (US)",
volume = "20",
pages = "1001--1009",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Bacterial vaccine vectors and bacillus calmette-guérin

AU - Cirillo, Jeffrey D.

AU - Stover, C. Kendall

AU - Bloom, Barry R.

AU - Jacobs, William R.

AU - Barletta, Raúl G.

PY - 1995/4

Y1 - 1995/4

N2 - Recent advances in biotechnology now allow a more modern approach to the development of vaccines, particularly that of recombinant vaccines, Bacterial vaccine vectors have the advantage over viral vectors in that the former have the ability to express a greater number of antigens in different forms. Although no recombinant bacterial vaccines are currently in use, bacillus Calmette-Guérin (BCG), Salmonella species, and Escherichia coli are being developed as vaccine vectors. We review plasmid systems and mutant strains developed for the expression of foreign antigens, with particular emphasis on those developed for BCG. We describe the development of antigen expression systems as well as the immune response elicited by recombinant BCG vaccine strains to bacterial and human immunodeficiency virus (HIV) antigens. A modified recombinant BCG carrier with selection for the stable maintenance of rDNA is proposed.

AB - Recent advances in biotechnology now allow a more modern approach to the development of vaccines, particularly that of recombinant vaccines, Bacterial vaccine vectors have the advantage over viral vectors in that the former have the ability to express a greater number of antigens in different forms. Although no recombinant bacterial vaccines are currently in use, bacillus Calmette-Guérin (BCG), Salmonella species, and Escherichia coli are being developed as vaccine vectors. We review plasmid systems and mutant strains developed for the expression of foreign antigens, with particular emphasis on those developed for BCG. We describe the development of antigen expression systems as well as the immune response elicited by recombinant BCG vaccine strains to bacterial and human immunodeficiency virus (HIV) antigens. A modified recombinant BCG carrier with selection for the stable maintenance of rDNA is proposed.

UR - http://www.scopus.com/inward/record.url?scp=0028961826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028961826&partnerID=8YFLogxK

U2 - 10.1093/clinids/20.4.1001

DO - 10.1093/clinids/20.4.1001

M3 - Article

C2 - 7795044

AN - SCOPUS:0028961826

VL - 20

SP - 1001

EP - 1009

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 4

ER -