Baclofen inhibits amygdala kindling in immature rats

John N.D. Wurpel, Ellen F. Sperber, Solomon L. Moshé

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The possible effectiveness of systemic infusions of baclofen (a GABAB receptor agonist) in the modification of seizures in developing animals has not yet been established. In this report, we studied the effects of systemic baclofen infusions on amygdala kindling in 16-day-old rat pups. Baclofen suppressed the development of kindling without altering the local afterdischarge threshold. Moreover, baclofen suppressed the severity and duration of established kindled seizures and increased the intensity of postictal refractoriness. The data suggest that baclofen may be a useful antiepileptic agent in this age group.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalEpilepsy Research
Volume5
Issue number1
DOIs
StatePublished - Jan 1 1990

Keywords

  • (Rat)
  • Amgydala
  • Baclofen
  • GABA
  • Kindling
  • Newborn
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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