Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP

Matthieu P.M.H. Benoit, Michael J. Plevin

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

TAR-RNA binding protein (TRBP) is a multidomain human protein involved in micro-RNA (miRNA) biogenesis. TRBP is a component of both the Dicer complex, which processes precursor miRNAs, and the RNA-induced silencing complex-loading complex. In addition, TRBP is implicated in the human immunodeficiency virus replication cycle and interferon-protein kinase R activity. TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2.

Original languageEnglish (US)
Pages (from-to)229-233
Number of pages5
JournalBiomolecular NMR Assignments
Volume7
Issue number2
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

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Keywords

  • Double-stranded RNA binding domain
  • Micro-RNA
  • TRBP
  • Triple resonance NMR experiments

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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