TY - JOUR
T1 - B lymphocyte antigen D8/17 and repetitive behaviors in autism
AU - Hollander, Eric
AU - DelGiudice-Asch, Gina
AU - Simon, Lorraine
AU - Schmeidler, James
AU - Cartwright, Charles
AU - DeCaria, Concetta M.
AU - Kwon, Jee
AU - Cunningham-Rundles, Charlotte
AU - Chapman, Floresta
AU - Zabriskie, John B.
PY - 1999/2/1
Y1 - 1999/2/1
N2 - Objective: Monoclonal antibody D8/17 identifies a B lymphocyte antigen with expanded expression in rheumatic fever, Sydenham's chorea, and subgroups of obsessive-compulsive disorder and Tourette's syndrome with repetitive behaviors. The authors examined the rate of D8/17 expression in children with autism and its correlation with severity of repetitive behaviors. Method: Blood samples from 18 patients with autism and 14 comparable medically ill children were evaluated for percentage of D8/17-positive B cells by immunofluorescence and for streptococcal antibodies. Severity of repetitive behaviors was also determined. Results: The frequency of individuals with ≥11% D8/17-positive cells was significantly higher in the autistic patients (78%) than the comparison subjects (21%), severity of repetitive behaviors significantly correlated with D8/17 expression, and D8/17-positive patients had significantly higher compulsion scores than D8/17-negative patients. Conclusions: D8/17 expression is high in patients with autism and may serve as a marker for compulsion severity within autism.
AB - Objective: Monoclonal antibody D8/17 identifies a B lymphocyte antigen with expanded expression in rheumatic fever, Sydenham's chorea, and subgroups of obsessive-compulsive disorder and Tourette's syndrome with repetitive behaviors. The authors examined the rate of D8/17 expression in children with autism and its correlation with severity of repetitive behaviors. Method: Blood samples from 18 patients with autism and 14 comparable medically ill children were evaluated for percentage of D8/17-positive B cells by immunofluorescence and for streptococcal antibodies. Severity of repetitive behaviors was also determined. Results: The frequency of individuals with ≥11% D8/17-positive cells was significantly higher in the autistic patients (78%) than the comparison subjects (21%), severity of repetitive behaviors significantly correlated with D8/17 expression, and D8/17-positive patients had significantly higher compulsion scores than D8/17-negative patients. Conclusions: D8/17 expression is high in patients with autism and may serve as a marker for compulsion severity within autism.
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M3 - Article
C2 - 9989573
AN - SCOPUS:0033059008
SN - 0002-953X
VL - 156
SP - 317
EP - 320
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 2
ER -
