B lymphocyte antigen D8/17 and repetitive behaviors in autism

Eric Hollander, Gina DelGiudice-Asch, Lorraine Simon, James Schmeidler, Charles Cartwright, Concetta M. DeCaria, Jee Kwon, Charlotte Cunningham-Rundles, Floresta Chapman, John B. Zabriskie

Research output: Contribution to journalArticle

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Abstract

Objective: Monoclonal antibody D8/17 identifies a B lymphocyte antigen with expanded expression in rheumatic fever, Sydenham's chorea, and subgroups of obsessive-compulsive disorder and Tourette's syndrome with repetitive behaviors. The authors examined the rate of D8/17 expression in children with autism and its correlation with severity of repetitive behaviors. Method: Blood samples from 18 patients with autism and 14 comparable medically ill children were evaluated for percentage of D8/17-positive B cells by immunofluorescence and for streptococcal antibodies. Severity of repetitive behaviors was also determined. Results: The frequency of individuals with ≥11% D8/17-positive cells was significantly higher in the autistic patients (78%) than the comparison subjects (21%), severity of repetitive behaviors significantly correlated with D8/17 expression, and D8/17-positive patients had significantly higher compulsion scores than D8/17-negative patients. Conclusions: D8/17 expression is high in patients with autism and may serve as a marker for compulsion severity within autism.

Original languageEnglish (US)
Pages (from-to)317-320
Number of pages4
JournalAmerican Journal of Psychiatry
Volume156
Issue number2
StatePublished - Feb 1999
Externally publishedYes

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Autistic Disorder
B-Lymphocytes
Antigens
Tourette Syndrome
Chorea
Rheumatic Fever
Obsessive-Compulsive Disorder
Fluorescent Antibody Technique
Monoclonal Antibodies
Antibodies

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hollander, E., DelGiudice-Asch, G., Simon, L., Schmeidler, J., Cartwright, C., DeCaria, C. M., ... Zabriskie, J. B. (1999). B lymphocyte antigen D8/17 and repetitive behaviors in autism. American Journal of Psychiatry, 156(2), 317-320.

B lymphocyte antigen D8/17 and repetitive behaviors in autism. / Hollander, Eric; DelGiudice-Asch, Gina; Simon, Lorraine; Schmeidler, James; Cartwright, Charles; DeCaria, Concetta M.; Kwon, Jee; Cunningham-Rundles, Charlotte; Chapman, Floresta; Zabriskie, John B.

In: American Journal of Psychiatry, Vol. 156, No. 2, 02.1999, p. 317-320.

Research output: Contribution to journalArticle

Hollander, E, DelGiudice-Asch, G, Simon, L, Schmeidler, J, Cartwright, C, DeCaria, CM, Kwon, J, Cunningham-Rundles, C, Chapman, F & Zabriskie, JB 1999, 'B lymphocyte antigen D8/17 and repetitive behaviors in autism', American Journal of Psychiatry, vol. 156, no. 2, pp. 317-320.
Hollander E, DelGiudice-Asch G, Simon L, Schmeidler J, Cartwright C, DeCaria CM et al. B lymphocyte antigen D8/17 and repetitive behaviors in autism. American Journal of Psychiatry. 1999 Feb;156(2):317-320.
Hollander, Eric ; DelGiudice-Asch, Gina ; Simon, Lorraine ; Schmeidler, James ; Cartwright, Charles ; DeCaria, Concetta M. ; Kwon, Jee ; Cunningham-Rundles, Charlotte ; Chapman, Floresta ; Zabriskie, John B. / B lymphocyte antigen D8/17 and repetitive behaviors in autism. In: American Journal of Psychiatry. 1999 ; Vol. 156, No. 2. pp. 317-320.
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AU - Cartwright, Charles

AU - DeCaria, Concetta M.

AU - Kwon, Jee

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