B cell lineage-specific activator protein (BSAP) a player at multiple stages of B cell development

J. S. Michaelson, M. Singh, B. K. Birshtein

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

B cell lineage-specific activator protein (BSAP), encoded by the Pax 5 gene, is a critical modulator of early B cell differentiation. Binding sites for BSAP have been identified in the promoters of multiple genes as well as at multiple sites within the IgH locus. While in vivo target sites critical for early B cell differentiation have not yet been identified, candidate sites include a 3' IgH enhancer that is active early in B cell development. BSAP may play an additional role later in development, such as in the regulation of isotype class switching.

Original languageEnglish (US)
Pages (from-to)2349-2351
Number of pages3
JournalJournal of Immunology
Volume156
Issue number7
StatePublished - 1996

Fingerprint

PAX5 Transcription Factor
Cell Lineage
Immunoglobulin Class Switching
B-Lymphocytes
Cell Differentiation
Genes
Binding Sites

ASJC Scopus subject areas

  • Immunology

Cite this

Michaelson, J. S., Singh, M., & Birshtein, B. K. (1996). B cell lineage-specific activator protein (BSAP) a player at multiple stages of B cell development. Journal of Immunology, 156(7), 2349-2351.

B cell lineage-specific activator protein (BSAP) a player at multiple stages of B cell development. / Michaelson, J. S.; Singh, M.; Birshtein, B. K.

In: Journal of Immunology, Vol. 156, No. 7, 1996, p. 2349-2351.

Research output: Contribution to journalArticle

Michaelson, JS, Singh, M & Birshtein, BK 1996, 'B cell lineage-specific activator protein (BSAP) a player at multiple stages of B cell development', Journal of Immunology, vol. 156, no. 7, pp. 2349-2351.
Michaelson, J. S. ; Singh, M. ; Birshtein, B. K. / B cell lineage-specific activator protein (BSAP) a player at multiple stages of B cell development. In: Journal of Immunology. 1996 ; Vol. 156, No. 7. pp. 2349-2351.
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