B cell lineage-specific activator protein (BSAP) a player at multiple stages of B cell development

J. S. Michaelson, M. Singh, B. K. Birshtein

Research output: Contribution to journalComment/debate

39 Scopus citations

Abstract

B cell lineage-specific activator protein (BSAP), encoded by the Pax 5 gene, is a critical modulator of early B cell differentiation. Binding sites for BSAP have been identified in the promoters of multiple genes as well as at multiple sites within the IgH locus. While in vivo target sites critical for early B cell differentiation have not yet been identified, candidate sites include a 3' IgH enhancer that is active early in B cell development. BSAP may play an additional role later in development, such as in the regulation of isotype class switching.

Original languageEnglish (US)
Pages (from-to)2349-2351
Number of pages3
JournalJournal of Immunology
Volume156
Issue number7
StatePublished - Apr 1 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Michaelson, J. S., Singh, M., & Birshtein, B. K. (1996). B cell lineage-specific activator protein (BSAP) a player at multiple stages of B cell development. Journal of Immunology, 156(7), 2349-2351.