Autotransplantation of cryopreserved parathyroid tissue in man

M. F. Brennan, E. M. Brown, A. M. Spiegel, S. J. Marx, J. L. Doppman, D. C. Jones, G. D. Aurbach

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Human cryopreserved parathyroid autografts have been performed in six patients following reoperative parathyroid surgery. All patients were rendered hypoparathyroid by their most recent reoperation. Parathyroid tissue was successfully autotransplanted after as long as eighteen months of cryopreservation. Viability and expected in vivo function of cryopreserved parathyroid tissue may be predicted by in vitro testing of parathyroid hormone secretion in response to varying ambient calcium concentration. Parathyroid cryopreservation with subsequent autotransplantation is a practical solution to the problem of permanent hypoparathyroidism that may follow multiple surgical procedures for persistent hyperparathyroidism.

Original languageEnglish (US)
Pages (from-to)139-142
Number of pages4
JournalUnknown Journal
Volume189
Issue number2
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Surgery

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    Brennan, M. F., Brown, E. M., Spiegel, A. M., Marx, S. J., Doppman, J. L., Jones, D. C., & Aurbach, G. D. (1979). Autotransplantation of cryopreserved parathyroid tissue in man. Unknown Journal, 189(2), 139-142. https://doi.org/10.1097/00000658-197902000-00002