TY - JOUR
T1 - Autophagy in neurons
T2 - it is not all about food
AU - Cuervo, Ana Maria
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/10
Y1 - 2006/10
N2 - The primary function of autophagy in most cell types is adaptation to starvation. Because neurons are protected from this type of stress, the physiological role of autophagy in normal functioning neurons was, until now, poorly understood. Using genetic manipulations to block autophagy in neurons selectively, Mizushima's and Tanaka's groups have recently presented conclusive evidence for an essential role of constitutive autophagy in neuronal survival. These studies provide new insights into the relationship between autophagy malfunctioning and neurodegenerative disorders.
AB - The primary function of autophagy in most cell types is adaptation to starvation. Because neurons are protected from this type of stress, the physiological role of autophagy in normal functioning neurons was, until now, poorly understood. Using genetic manipulations to block autophagy in neurons selectively, Mizushima's and Tanaka's groups have recently presented conclusive evidence for an essential role of constitutive autophagy in neuronal survival. These studies provide new insights into the relationship between autophagy malfunctioning and neurodegenerative disorders.
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U2 - 10.1016/j.molmed.2006.08.003
DO - 10.1016/j.molmed.2006.08.003
M3 - Short survey
C2 - 16931158
AN - SCOPUS:33748972664
SN - 1471-4914
VL - 12
SP - 461
EP - 464
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 10
ER -