Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development

Nuria Martinez-Lopez, Diana Athonvarangkul, Srabani Sahu, Luisa Coletto, Haihong Zong, Claire C. Bastie, Jeffrey E. Pessin, Gary J. Schwartz, Rajat Singh

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Macroautophagy (MA) regulates cellular quality control and energy balance. For example, loss of MA in aP2-positive adipocytes converts white adipose tissue (WAT) into brown adipose tissue (BAT)-like, enhancing BAT function and thereby insulin sensitivity. However, whether MA regulates early BAT development is unknown. We report that deleting Atg7 in myogenic Myf5+ progenitors inhibits MA in Myf5-cell-derived BAT and muscle. Knock out (KO) mice have defective BAT differentiation and function. Surprisingly, their body temperature is higher due to WAT lipolysis-driven increases in fatty acid oxidation in 'Beige' cells in inguinal WAT, BAT and muscle. KO mice also present impaired muscle differentiation, reduced muscle mass and glucose intolerance. Our studies show that ATG7 in Myf5+ progenitors is required to maintain energy and glucose homeostasis through effects on BAT and muscle development. Decreased MA in myogenic progenitors with age and/or overnutrition might contribute to the metabolic defects and sarcopenia observed in these conditions.

Original languageEnglish (US)
Pages (from-to)795-803
Number of pages9
JournalEMBO Reports
Volume14
Issue number9
DOIs
StatePublished - Sep 2013

Fingerprint

Brown Adipose Tissue
Muscle Development
Autophagy
Muscle
Skeletal Muscle
Homeostasis
Fats
Tissue
Glucose
White Adipose Tissue
Muscles
Knockout Mice
Overnutrition
Sarcopenia
Glucose Intolerance
Groin
Lipolysis
Body Temperature
Adipocytes
Quality Control

Keywords

  • Autophagy
  • Brown fat
  • Myf5+ progenitors

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

Cite this

Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. / Martinez-Lopez, Nuria; Athonvarangkul, Diana; Sahu, Srabani; Coletto, Luisa; Zong, Haihong; Bastie, Claire C.; Pessin, Jeffrey E.; Schwartz, Gary J.; Singh, Rajat.

In: EMBO Reports, Vol. 14, No. 9, 09.2013, p. 795-803.

Research output: Contribution to journalArticle

Martinez-Lopez, Nuria ; Athonvarangkul, Diana ; Sahu, Srabani ; Coletto, Luisa ; Zong, Haihong ; Bastie, Claire C. ; Pessin, Jeffrey E. ; Schwartz, Gary J. ; Singh, Rajat. / Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. In: EMBO Reports. 2013 ; Vol. 14, No. 9. pp. 795-803.
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