Atypical Psychosis With Disseminated Subpial Demyelination

Paul E. Neumann, Mark F. Mehler, Dikran S. Horoupian, Arnold E. Merriam

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 34-year-old woman experienced three episodes of an atypical psychosis, characterized by confusion, agitation, delusional thinking, paranoid ideation, and auditory hallucinations, during the 14 months prior to her death. Findings of gross examination of the brain and spinal cord were unremarkable. Histologic examination revealed scattered subpial foci of demyelination throughout the brain stem, with involvement of the hippocampal formation bilaterally. Although occasional active lesions at early stages of development were noted, most lesions were gliotic and therefore quiescent. This case and one similar example of disseminated subpial demyelination found in the literature probably represent an unusual variant of multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)634-636
Number of pages3
JournalArchives of Neurology
Volume45
Issue number6
DOIs
StatePublished - 1988

Fingerprint

Demyelinating Diseases
Psychotic Disorders
Confusion
Hallucinations
Brain Stem
Multiple Sclerosis
Hippocampus
Spinal Cord
Brain
Psychosis
Lesion
Thinking
Cord
Auditory Hallucinations

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Atypical Psychosis With Disseminated Subpial Demyelination. / Neumann, Paul E.; Mehler, Mark F.; Horoupian, Dikran S.; Merriam, Arnold E.

In: Archives of Neurology, Vol. 45, No. 6, 1988, p. 634-636.

Research output: Contribution to journalArticle

Neumann, Paul E. ; Mehler, Mark F. ; Horoupian, Dikran S. ; Merriam, Arnold E. / Atypical Psychosis With Disseminated Subpial Demyelination. In: Archives of Neurology. 1988 ; Vol. 45, No. 6. pp. 634-636.
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