Atypical monoclonal plasma cell hyperplasia of the central nervous system: Precursor of plasmacytoma with evolutionary considerations

Karen M. Weidenheim, W. G. Campbell, H. W. Goldman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Hematopoietic proliferations rich in plasma cells rarely occur within the central nervous system without the involvement of other organ systems. Depending on their histological pattern and cellular composition, several different terms, including plasmacytoma, plasma cell granuloma, hyalinizing plasmacytic granulomatosis, and inflammatory meningioma, are used for these lesions. We report a left temporal dural lesion composed of plasma cells, lymphocytes, histiocytes, and rare eosinophils with hyaline changes and a suggestion of follicle formation, which stained predominantly for IgG and kappa light chains. This lesion arose in an otherwise healthy 52-year-old woman. Free kappa light chains without a monoclonal peak were found in the urine. We are aware of only two other heterogeneous, predominantly plasmacytic, solitary dural lesions that were found to be monoclonal on immunohistochemical examination. The label atypical monoclonal plasma cell hyperplasia appears to suit the morphological characteristics of our lesion. We suggest that a spectrum of solitary plasmacytic lesions may occur within the central nervous system and that atypical plasma cell hyperplasias have the potential to evolve into plasmacytoma. The preneoplastic nature of this lesion and its potential for evolution to malignant myeloma should be considered when planning treatment and lifelong follow-up for patients.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalNeurosurgery
Volume24
Issue number3
StatePublished - 1989
Externally publishedYes

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Plasmacytoma
Plasma Cells
Hyperplasia
Central Nervous System
Plasma Cell Granuloma
Light
Hyalin
Histiocytes
Meningioma
Eosinophils
Immunoglobulin G
Urine
Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Atypical monoclonal plasma cell hyperplasia of the central nervous system : Precursor of plasmacytoma with evolutionary considerations. / Weidenheim, Karen M.; Campbell, W. G.; Goldman, H. W.

In: Neurosurgery, Vol. 24, No. 3, 1989, p. 429-434.

Research output: Contribution to journalArticle

Weidenheim, Karen M. ; Campbell, W. G. ; Goldman, H. W. / Atypical monoclonal plasma cell hyperplasia of the central nervous system : Precursor of plasmacytoma with evolutionary considerations. In: Neurosurgery. 1989 ; Vol. 24, No. 3. pp. 429-434.
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