TY - JOUR
T1 - Atrial fibrillation and cardiac resynchronization therapy
T2 - The MASCOT study
AU - Padeletti, Luigi
AU - Musilli, Nicola
AU - Porciani, Maria Cristina
AU - Colella, Andrea
AU - Di Biase, Luigi
AU - Ricciardi, Giuseppe
AU - Pieragnoli, Paolo
AU - Michelucci, Antonio
AU - Gensini, Gian Franco
PY - 2004/9
Y1 - 2004/9
N2 - Atrial fibrillation (AF) and congestive heart failure (CHF) share several characteristics and often coexist in the same patient. Both are responsible for significant morbidity and mortality, are increasing in prevalence, and are major sources of health expenditure. The Management of Atrial fibrillation Suppression in AF-HF COmorbidity Therapy (MASCOT) study is a European, single-blind, prospective, controlled, multicentre, randomized clinical trial designed to examine whether adding the AF Suppression™ Algorithm to cardiac resynchronization therapy (CRT) improves the prognosis of patients with CHF. The patients will be randomly assigned to a CRT-only group, with the AF Suppression™ algorithm programmed OFF (control group), versus a CRT + AF Suppression™ group, with the algorithm programmed ON (treatment group). The primary study endpoint is development of permanent AF, and secondary endpoints are safety of the AF Suppression™ algorithm, and evolution of multiple clinical variables over 24 months of follow-up. CRT combined with a refined atrial tachyarrhythmia prevention pacing algorithm may represent a major advance in the management of AF and CHF by electrical stimulation.
AB - Atrial fibrillation (AF) and congestive heart failure (CHF) share several characteristics and often coexist in the same patient. Both are responsible for significant morbidity and mortality, are increasing in prevalence, and are major sources of health expenditure. The Management of Atrial fibrillation Suppression in AF-HF COmorbidity Therapy (MASCOT) study is a European, single-blind, prospective, controlled, multicentre, randomized clinical trial designed to examine whether adding the AF Suppression™ Algorithm to cardiac resynchronization therapy (CRT) improves the prognosis of patients with CHF. The patients will be randomly assigned to a CRT-only group, with the AF Suppression™ algorithm programmed OFF (control group), versus a CRT + AF Suppression™ group, with the algorithm programmed ON (treatment group). The primary study endpoint is development of permanent AF, and secondary endpoints are safety of the AF Suppression™ algorithm, and evolution of multiple clinical variables over 24 months of follow-up. CRT combined with a refined atrial tachyarrhythmia prevention pacing algorithm may represent a major advance in the management of AF and CHF by electrical stimulation.
KW - Atrial fibrillation
KW - Atrial pacing
KW - Cardiac resynchronization therapy
KW - Overdrive pacing
UR - http://www.scopus.com/inward/record.url?scp=4444227512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4444227512&partnerID=8YFLogxK
U2 - 10.1016/j.eupc.2004.07.007
DO - 10.1016/j.eupc.2004.07.007
M3 - Article
C2 - 15450280
AN - SCOPUS:4444227512
SN - 1099-5129
VL - 5
SP - S49-S54
JO - Europace
JF - Europace
IS - SUPPL. 1
ER -