Atomic motion in enzymatic reaction coordinates

Vern L. Schramm, Wuxian Shi

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Atomic excursions of reactants in enzymatic catalytic sites can be estimated from high-resolution crystal structures of enzyme complexes with substrates, transition state analog inhibitors and products. Transition state structures, defined from kinetic isotope effect studies, are compared to crystallographic structures to validate the properties of the transition state analog. Atomic excursions in enzymatic catalytic sites can differ from those in solution and define the role of the enzymatic catalyst in directing atomic motion.

Original languageEnglish (US)
Pages (from-to)657-665
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume11
Issue number6
DOIs
StatePublished - Dec 1 2001

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Catalytic Domain
Isotopes
Enzymes

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

Atomic motion in enzymatic reaction coordinates. / Schramm, Vern L.; Shi, Wuxian.

In: Current Opinion in Structural Biology, Vol. 11, No. 6, 01.12.2001, p. 657-665.

Research output: Contribution to journalArticle

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