Astrocytes: Targets and mediators of chemical-induced CNS injury

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

It is now well established that a reciprocal relationship exists between neurons and astrocytes, and that this association is vital for mutual differentiation, development, and functioning of both cell types. It had also become apparent that perturbations in astrocytic function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of astrocytic-neuronal interactions. The purpose of this review is to explore astrocytic-neuronal interactions, focusing on potential sites of neurotoxicant actions. In developing this thesis, we briefly examine the functional interactions between astrocytes and neurons, followed by specific examples of astrocyte-mediated neurotoxicity.

Original languageEnglish (US)
Pages (from-to)329-342
Number of pages14
JournalJournal of Toxicology and Environmental Health
Volume38
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Astrocytes
Neurons
Wounds and Injuries
Association reactions

ASJC Scopus subject areas

  • Pollution
  • Toxicology

Cite this

@article{1b1f23eae0ee435ba4e34ac43cca257a,
title = "Astrocytes: Targets and mediators of chemical-induced CNS injury",
abstract = "It is now well established that a reciprocal relationship exists between neurons and astrocytes, and that this association is vital for mutual differentiation, development, and functioning of both cell types. It had also become apparent that perturbations in astrocytic function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of astrocytic-neuronal interactions. The purpose of this review is to explore astrocytic-neuronal interactions, focusing on potential sites of neurotoxicant actions. In developing this thesis, we briefly examine the functional interactions between astrocytes and neurons, followed by specific examples of astrocyte-mediated neurotoxicity.",
author = "Michael Aschner and LoPachin, {Richard M.}",
year = "1993",
language = "English (US)",
volume = "38",
pages = "329--342",
journal = "Journal of Toxicology and Environmental Health - Part A: Current Issues",
issn = "1528-7394",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Astrocytes

T2 - Targets and mediators of chemical-induced CNS injury

AU - Aschner, Michael

AU - LoPachin, Richard M.

PY - 1993

Y1 - 1993

N2 - It is now well established that a reciprocal relationship exists between neurons and astrocytes, and that this association is vital for mutual differentiation, development, and functioning of both cell types. It had also become apparent that perturbations in astrocytic function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of astrocytic-neuronal interactions. The purpose of this review is to explore astrocytic-neuronal interactions, focusing on potential sites of neurotoxicant actions. In developing this thesis, we briefly examine the functional interactions between astrocytes and neurons, followed by specific examples of astrocyte-mediated neurotoxicity.

AB - It is now well established that a reciprocal relationship exists between neurons and astrocytes, and that this association is vital for mutual differentiation, development, and functioning of both cell types. It had also become apparent that perturbations in astrocytic function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of astrocytic-neuronal interactions. The purpose of this review is to explore astrocytic-neuronal interactions, focusing on potential sites of neurotoxicant actions. In developing this thesis, we briefly examine the functional interactions between astrocytes and neurons, followed by specific examples of astrocyte-mediated neurotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=0027526497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027526497&partnerID=8YFLogxK

M3 - Article

C2 - 8450560

AN - SCOPUS:0027526497

VL - 38

SP - 329

EP - 342

JO - Journal of Toxicology and Environmental Health - Part A: Current Issues

JF - Journal of Toxicology and Environmental Health - Part A: Current Issues

SN - 1528-7394

IS - 3

ER -