Astrocytes take the stage in a tale of signaling-metabolism coupling

Lasse K. Bak, Jeffrey E. Pessin

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Astrocytes are crucial cells in the brain that are intimately coupled with neuronal metabolism. A new paper from San Martín et al. provides evidence that physiological levels of the gaseous signal molecule NO can rapidly and reversibly increase astrocyte metabolism of glucose and production of lactate. A proposed neurological coupling - from the potential source of NO, endothelial cells, to the potential beneficiary from the lactate, neurons - prompts new questions regarding the controversial role of lactate in the brain.

Original languageEnglish (US)
Pages (from-to)9439-9440
Number of pages2
JournalJournal of Biological Chemistry
Issue number22
StatePublished - Jun 2 2017

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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