Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): Mechanism of induction and role in antiviral response

Agriculture & Biology

• Toll-like receptor 3 100%
• indoleamine 2,3-dioxygenase 95%
• polyinosinic-polycytidylic acid 80%
• astrocytes 68%
• ligands 51%
• interferons 27%
• interferon regulatory factor-3 14%
• encephalitis 9%
• tryptophan 7%
• cytokines 7%
• nitric oxide 7%
• kynurenine pathway 6%
• viral diseases of animals and humans 6%
• antiviral proteins 6%
• protein synthesis 6%
• Human betaherpesvirus 5 6%
• Human immunodeficiency virus 5%
• Vesiculovirus 5%
• neurotoxicity 4%
• interleukin-1 4%
• interferon-gamma 4%
• neuroglia 4%
• double-stranded RNA 4%
• G-proteins 4%
• RNA interference 4%
• central nervous system 4%
• T-lymphocytes 3%
• macrophages 3%
• therapeutics 3%
• enzyme activity 2%
• metabolism 2%
• enzymes 1%
• genes 1%

Medicine & Life Sciences

• Toll-Like Receptor 3 80%
• Indoleamine-Pyrrole 2,3,-Dioxygenase 76%
• Poly I-C 71%
• Astrocytes 52%
• Antiviral Agents 48%
• Ligands 39%
• Interferons 22%
• Interferon Regulatory Factor-3 11%
• Encephalitis 8%
• Tryptophan 8%
• HIV 8%
• vesicular stomatitis virus G protein 6%
• Nitric Oxide 6%
• Kynurenine 5%
• Cytokines 5%
• Double-Stranded RNA 4%
• Proteins 4%
• Enzymes 4%
• Microglia 4%
• Interleukin-1 4%
• Cytomegalovirus 4%
• RNA Interference 3%
• Interferon-gamma 3%
• Central Nervous System 2%
• Virus Diseases 2%
• Macrophages 2%
• T-Lymphocytes 2%
• Genes 1%
• Therapeutics 0%