Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women

Rachel P. Wildman, Dan Wang, Ivonne Fernandez, Peter Mancuso, Nanette Santoro, Philipp E. Scherer, Maryfran R. Sowers

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Regulators of adipose tissue hormones remain incompletely understood, but may include sex hormones. As adipose tissue hormones have been shown to contribute to numerous metabolic and cardiovascular disorders, understanding their regulation in midlife women is of clinical importance. Therefore, we assessed the associations between testosterone (T) and sex hormone binding globulin (SHBG) with leptin, high molecular weight (HMW) adiponectin, and the soluble form of the leptin receptor (sOB-R) in healthy midlife women. Design and Methods: Cross-sectional analyses were performed using data from 1,881 midlife women (average age 52.6 (±2.7) years) attending the sixth Annual follow-up visit of the multiethnic Study of Women's Health Across the Nation. Results: T was weakly negatively associated with both HMW adiponectin and sOB-R (r = -0.12 and r = -0.10, respectively; P < 0.001 for both), and positively associated with leptin (r = 0.17; P < 0.001). SHBG was more strongly and positively associated with both HMW adiponectin and sOB-R (r = 0.29 and r = 0.24, respectively; P < 0.001 for both), and more strongly and negatively associated with leptin (r = -0.27; P < 0.001). Adjustment for fat mass, insulin resistance, or waist circumference only partially diminished associations with HMW adiponectin and sOB-R, but attenuated associations with leptin. In conclusion, in these midlife women, lower SHBG values, and to a lesser extent, higher T levels, were associated with lower, or less favorable, levels of adiponectin and sOB-R, independent of fat mass. Conclusions: These data suggest that variation in these adipose hormones resulting from lower SHBG levels, and possibly, though less likely, greater androgenicity, may contribute to susceptibility for metabolic and cardiovascular outcomes during midlife in women.

Original languageEnglish (US)
Pages (from-to)629-636
Number of pages8
JournalObesity
Volume21
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Sex Hormone-Binding Globulin
Adiponectin
Testosterone
Adipose Tissue
Leptin
Hormones
Molecular Weight
Fats
Leptin Receptors
Gonadal Steroid Hormones
Waist Circumference
Women's Health
Insulin Resistance
Cross-Sectional Studies

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Wildman, R. P., Wang, D., Fernandez, I., Mancuso, P., Santoro, N., Scherer, P. E., & Sowers, M. R. (2013). Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women. Obesity, 21(3), 629-636. https://doi.org/10.1002/oby.20256

Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women. / Wildman, Rachel P.; Wang, Dan; Fernandez, Ivonne; Mancuso, Peter; Santoro, Nanette; Scherer, Philipp E.; Sowers, Maryfran R.

In: Obesity, Vol. 21, No. 3, 03.2013, p. 629-636.

Research output: Contribution to journalArticle

Wildman, RP, Wang, D, Fernandez, I, Mancuso, P, Santoro, N, Scherer, PE & Sowers, MR 2013, 'Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women', Obesity, vol. 21, no. 3, pp. 629-636. https://doi.org/10.1002/oby.20256
Wildman RP, Wang D, Fernandez I, Mancuso P, Santoro N, Scherer PE et al. Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women. Obesity. 2013 Mar;21(3):629-636. https://doi.org/10.1002/oby.20256
Wildman, Rachel P. ; Wang, Dan ; Fernandez, Ivonne ; Mancuso, Peter ; Santoro, Nanette ; Scherer, Philipp E. ; Sowers, Maryfran R. / Associations of testosterone and sex hormone binding globulin with adipose tissue hormones in midlife women. In: Obesity. 2013 ; Vol. 21, No. 3. pp. 629-636.
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