Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older chinese people

Zhijie Yu, Xingwang Ye, Jing Wang, Qibin Qi, Oscar H. Franco, Kirsten L. Rennie, An Pan, Huaixing Li, Yong Liu, Frank B. Hu, Xu Lin

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

BACKGROUND: Inflammatory factors, adipocytokines, and the metabolic syndrome are important determinants of cardiometabolic disease. It remains unclear how physical activity is related to these risk factors. Our objective was to investigate single and joint associations of physical activity with inflammatory factors, adipocytokines, and the metabolic syndrome among middle-aged and older Chinese people. METHODS AND RESULTS: A total of 3289 individuals (1458 men, 1831 women) 50 to 70 years of age participated in a population-based cross-sectional survey in Beijing and Shanghai, China. Levels of total physical activity were assessed with the International Physical Activity Questionnaire. High-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-± receptor 2, adiponectin, and retinol-binding protein 4 were measured. The metabolic syndrome was defined using the updated National Cholesterol Education Program/Adult Treatment Panel III criteria for Asian Americans. Plasma concentrations of high-sensitivity C-reactive protein were 1.58, 1.74, and 1.27 mg/L (P≤0.0138) and of adiponectin were 16.12, 16.20, and 17.21 mg/L (P≤0.0078) among individuals with low, medium, and high levels of total physical activity, respectively, with adjustment for potential confounders. In the multivariable-adjusted logistic regression analyses, participants with higher levels of total physical activity had a lower risk of having the metabolic syndrome (odds ratio, 0.68; 95% confidence interval, 0.54 to 0.85; P for trend≤0.001) compared with those with lower levels. CONCLUSIONS: Being physically active is associated with a better profile of inflammatory factors and adipocytokines and a reduced risk of having the metabolic syndrome among Chinese people.

Original languageEnglish (US)
Pages (from-to)2969-2977
Number of pages9
JournalCirculation
Volume119
Issue number23
DOIs
StatePublished - Jun 16 2009
Externally publishedYes

Fingerprint

Adipokines
Exercise
Adiponectin
C-Reactive Protein
Receptors, Tumor Necrosis Factor, Type II
Retinol-Binding Proteins
Asian Americans
Interleukin-6
China
Cross-Sectional Studies
Logistic Models
Odds Ratio
Cholesterol
Regression Analysis
Confidence Intervals
Education
Population

Keywords

  • Adipocytokines
  • Cross-sectional studies
  • Exercise
  • Inflammation
  • Metabolic syndrome

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older chinese people. / Yu, Zhijie; Ye, Xingwang; Wang, Jing; Qi, Qibin; Franco, Oscar H.; Rennie, Kirsten L.; Pan, An; Li, Huaixing; Liu, Yong; Hu, Frank B.; Lin, Xu.

In: Circulation, Vol. 119, No. 23, 16.06.2009, p. 2969-2977.

Research output: Contribution to journalArticle

Yu, Zhijie ; Ye, Xingwang ; Wang, Jing ; Qi, Qibin ; Franco, Oscar H. ; Rennie, Kirsten L. ; Pan, An ; Li, Huaixing ; Liu, Yong ; Hu, Frank B. ; Lin, Xu. / Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older chinese people. In: Circulation. 2009 ; Vol. 119, No. 23. pp. 2969-2977.
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abstract = "BACKGROUND: Inflammatory factors, adipocytokines, and the metabolic syndrome are important determinants of cardiometabolic disease. It remains unclear how physical activity is related to these risk factors. Our objective was to investigate single and joint associations of physical activity with inflammatory factors, adipocytokines, and the metabolic syndrome among middle-aged and older Chinese people. METHODS AND RESULTS: A total of 3289 individuals (1458 men, 1831 women) 50 to 70 years of age participated in a population-based cross-sectional survey in Beijing and Shanghai, China. Levels of total physical activity were assessed with the International Physical Activity Questionnaire. High-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-± receptor 2, adiponectin, and retinol-binding protein 4 were measured. The metabolic syndrome was defined using the updated National Cholesterol Education Program/Adult Treatment Panel III criteria for Asian Americans. Plasma concentrations of high-sensitivity C-reactive protein were 1.58, 1.74, and 1.27 mg/L (P≤0.0138) and of adiponectin were 16.12, 16.20, and 17.21 mg/L (P≤0.0078) among individuals with low, medium, and high levels of total physical activity, respectively, with adjustment for potential confounders. In the multivariable-adjusted logistic regression analyses, participants with higher levels of total physical activity had a lower risk of having the metabolic syndrome (odds ratio, 0.68; 95{\%} confidence interval, 0.54 to 0.85; P for trend≤0.001) compared with those with lower levels. CONCLUSIONS: Being physically active is associated with a better profile of inflammatory factors and adipocytokines and a reduced risk of having the metabolic syndrome among Chinese people.",
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T1 - Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older chinese people

AU - Yu, Zhijie

AU - Ye, Xingwang

AU - Wang, Jing

AU - Qi, Qibin

AU - Franco, Oscar H.

AU - Rennie, Kirsten L.

AU - Pan, An

AU - Li, Huaixing

AU - Liu, Yong

AU - Hu, Frank B.

AU - Lin, Xu

PY - 2009/6/16

Y1 - 2009/6/16

N2 - BACKGROUND: Inflammatory factors, adipocytokines, and the metabolic syndrome are important determinants of cardiometabolic disease. It remains unclear how physical activity is related to these risk factors. Our objective was to investigate single and joint associations of physical activity with inflammatory factors, adipocytokines, and the metabolic syndrome among middle-aged and older Chinese people. METHODS AND RESULTS: A total of 3289 individuals (1458 men, 1831 women) 50 to 70 years of age participated in a population-based cross-sectional survey in Beijing and Shanghai, China. Levels of total physical activity were assessed with the International Physical Activity Questionnaire. High-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-± receptor 2, adiponectin, and retinol-binding protein 4 were measured. The metabolic syndrome was defined using the updated National Cholesterol Education Program/Adult Treatment Panel III criteria for Asian Americans. Plasma concentrations of high-sensitivity C-reactive protein were 1.58, 1.74, and 1.27 mg/L (P≤0.0138) and of adiponectin were 16.12, 16.20, and 17.21 mg/L (P≤0.0078) among individuals with low, medium, and high levels of total physical activity, respectively, with adjustment for potential confounders. In the multivariable-adjusted logistic regression analyses, participants with higher levels of total physical activity had a lower risk of having the metabolic syndrome (odds ratio, 0.68; 95% confidence interval, 0.54 to 0.85; P for trend≤0.001) compared with those with lower levels. CONCLUSIONS: Being physically active is associated with a better profile of inflammatory factors and adipocytokines and a reduced risk of having the metabolic syndrome among Chinese people.

AB - BACKGROUND: Inflammatory factors, adipocytokines, and the metabolic syndrome are important determinants of cardiometabolic disease. It remains unclear how physical activity is related to these risk factors. Our objective was to investigate single and joint associations of physical activity with inflammatory factors, adipocytokines, and the metabolic syndrome among middle-aged and older Chinese people. METHODS AND RESULTS: A total of 3289 individuals (1458 men, 1831 women) 50 to 70 years of age participated in a population-based cross-sectional survey in Beijing and Shanghai, China. Levels of total physical activity were assessed with the International Physical Activity Questionnaire. High-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-± receptor 2, adiponectin, and retinol-binding protein 4 were measured. The metabolic syndrome was defined using the updated National Cholesterol Education Program/Adult Treatment Panel III criteria for Asian Americans. Plasma concentrations of high-sensitivity C-reactive protein were 1.58, 1.74, and 1.27 mg/L (P≤0.0138) and of adiponectin were 16.12, 16.20, and 17.21 mg/L (P≤0.0078) among individuals with low, medium, and high levels of total physical activity, respectively, with adjustment for potential confounders. In the multivariable-adjusted logistic regression analyses, participants with higher levels of total physical activity had a lower risk of having the metabolic syndrome (odds ratio, 0.68; 95% confidence interval, 0.54 to 0.85; P for trend≤0.001) compared with those with lower levels. CONCLUSIONS: Being physically active is associated with a better profile of inflammatory factors and adipocytokines and a reduced risk of having the metabolic syndrome among Chinese people.

KW - Adipocytokines

KW - Cross-sectional studies

KW - Exercise

KW - Inflammation

KW - Metabolic syndrome

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