Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer

Ryan J. Burri, Richard G. Stock, Jamie A. Cesaretti, David P. Atencio, Sheila Peters, Christopher A. Peters, Grace Fan, Nelson N. Stone, Harry Ostrer, Barry S. Rosenstein

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The objective of this study was to determine whether an association exists between certain single nucleotide polymorphisms (SNPs), which have previously been linked with adverse normal tissue effects resulting from radiotherapy, and the development of radiation injury resulting from radiotherapy for prostate cancer. A total of 135 consecutive patients with clinically localized prostate cancer and a minimum of 1 year of follow-up who had been treated with radiation therapy, either brachytherapy alone or in combination with external-beam radiotherapy, with or without hormone therapy, were genotyped for SNPs in SOD2, XRCC1 and XRCC3. Three common late tissue toxicities were investigated: late rectal bleeding, urinary morbidity, and erectile dysfunction. Patients with the XRCC1 rs25489 G/A (Arg280His) genotype were more likely to develop erectile dysfunction after irradiation than patients who had the G/G genotype (67% compared to 24%; P = 0.048). In addition, patients who had the SOD2 rs4880 T/C (Val16Ala) genotype exhibited a significant increase in grade 2 late rectal bleeding compared to patients who had either the C/C or T/T genotype for this SNP (8% compared to 0%; P = 0.02). Finally, patients with the combination of the SOD2 rs4880 C/T genotype and XRCC3 rs861539 T/C (Thr241Met) genotype experienced a significant increase in grade 2 late rectal bleeding compared to patients without this particular genotypic arrangement (14% compared to 1%; P = 0.002). These results suggest that SNPs in the SOD2, XRCC1 and XRCC3 genes are associated with the development of late radiation injury in patients treated with radiation therapy for prostate adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)49-59
Number of pages11
JournalRadiation Research
Volume170
Issue number1
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

polymorphism
nucleotides
prostatic neoplasms
radiotherapy
single nucleotide polymorphism
Single Nucleotide Polymorphism
radiation therapy
Prostatic Neoplasms
Radiotherapy
cancer
adverse effects
magnetic permeability
Genotype
bleeding
genotype
radiation injury
radiation injuries
hemorrhage
Radiation Injuries
Erectile Dysfunction

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer. / Burri, Ryan J.; Stock, Richard G.; Cesaretti, Jamie A.; Atencio, David P.; Peters, Sheila; Peters, Christopher A.; Fan, Grace; Stone, Nelson N.; Ostrer, Harry; Rosenstein, Barry S.

In: Radiation Research, Vol. 170, No. 1, 07.2008, p. 49-59.

Research output: Contribution to journalArticle

Burri, Ryan J. ; Stock, Richard G. ; Cesaretti, Jamie A. ; Atencio, David P. ; Peters, Sheila ; Peters, Christopher A. ; Fan, Grace ; Stone, Nelson N. ; Ostrer, Harry ; Rosenstein, Barry S. / Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer. In: Radiation Research. 2008 ; Vol. 170, No. 1. pp. 49-59.
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abstract = "The objective of this study was to determine whether an association exists between certain single nucleotide polymorphisms (SNPs), which have previously been linked with adverse normal tissue effects resulting from radiotherapy, and the development of radiation injury resulting from radiotherapy for prostate cancer. A total of 135 consecutive patients with clinically localized prostate cancer and a minimum of 1 year of follow-up who had been treated with radiation therapy, either brachytherapy alone or in combination with external-beam radiotherapy, with or without hormone therapy, were genotyped for SNPs in SOD2, XRCC1 and XRCC3. Three common late tissue toxicities were investigated: late rectal bleeding, urinary morbidity, and erectile dysfunction. Patients with the XRCC1 rs25489 G/A (Arg280His) genotype were more likely to develop erectile dysfunction after irradiation than patients who had the G/G genotype (67{\%} compared to 24{\%}; P = 0.048). In addition, patients who had the SOD2 rs4880 T/C (Val16Ala) genotype exhibited a significant increase in grade 2 late rectal bleeding compared to patients who had either the C/C or T/T genotype for this SNP (8{\%} compared to 0{\%}; P = 0.02). Finally, patients with the combination of the SOD2 rs4880 C/T genotype and XRCC3 rs861539 T/C (Thr241Met) genotype experienced a significant increase in grade 2 late rectal bleeding compared to patients without this particular genotypic arrangement (14{\%} compared to 1{\%}; P = 0.002). These results suggest that SNPs in the SOD2, XRCC1 and XRCC3 genes are associated with the development of late radiation injury in patients treated with radiation therapy for prostate adenocarcinoma.",
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