Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials

Glenn R. Cunningham, Alisa J. Stephens-Shields, Raymond C. Rosen, Christina Wang, Susan S. Ellenberg, Alvin M. Matsumoto, Shalender Bhasin, Mark E. Molitch, John T. Farrar, David Cella, Elizabeth Barrett-Connor, Jane A. Cauley, Denise Cifelli, Jill P. Crandall, Kristine E. Ensrud, Laura Fluharty, Thomas M. Gill, Cora E. Lewis, Marco Pahor, Susan M. ResnickThomas W. Storer, Ronald S. Swerdloff, Stephen Anton, Shehzad Basaria, Susan Diem, Vafa Tabatabaie, Xiaoling Hou, Peter J. Snyder

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Context: The prevalence of sexual dysfunction, low vitality, and poor physical function increases with aging, as does the prevalence of low total and free testosterone (TT and FT) levels. However, the relationship between sex hormones and age-related alterations in older men is not clear. Objective: To test the hypotheses that baseline serum TT, FT, estradiol (E2), and sex hormone-binding globulin (SHBG) levels are independently associated with sexual function, vitality, and physical function in older symptomatic men with low testosterone levels participating in the Testosterone Trials (TTrials). Design: Cross-sectional study of baseline measures in the TTrials. Setting: The study was conducted at 12 sites in the United States. Participants: The 788 TTrials participants were ≥ 65 years and had evidence of sexual dysfunction, diminished vitality, and/or mobility disability, and an average of two TT < 275 ng/dL. Interventions: None. Main Outcome Measures: Question 4 of Psychosocial Daily Questionnaire (PDQ-Q4), the FACIT-Fatigue Scale, and the 6-minute walk test. Results: Baseline serum TT and FT, but not E2 or SHBG levels had small, but statistically significant associations with validated measures of sexual desire, erectile function, and sexual activity. None of these hormones was significantly associated within or across trials with FACIT-Fatigue, PHQ-9 Depression or Physical Function-10 scores, or gait speed. Conclusions: FT and TT levels were consistently, independently, and positively associated, albeit to a small degree, with measures of sexual desire, erectile function, and sexual activity, but not with measures of vitality or physical function in symptomatic older men with low T who qualified for the TTrials.

Original languageEnglish (US)
Pages (from-to)1146-1155
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number3
DOIs
StatePublished - Mar 1 2015

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Gonadal Steroid Hormones
Testosterone
Sex Hormone-Binding Globulin
Sexual Behavior
Fatigue
Fatigue of materials
Serum
Estradiol
Cross-Sectional Studies
Aging of materials
Outcome Assessment (Health Care)
Hormones
Depression

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials. / Cunningham, Glenn R.; Stephens-Shields, Alisa J.; Rosen, Raymond C.; Wang, Christina; Ellenberg, Susan S.; Matsumoto, Alvin M.; Bhasin, Shalender; Molitch, Mark E.; Farrar, John T.; Cella, David; Barrett-Connor, Elizabeth; Cauley, Jane A.; Cifelli, Denise; Crandall, Jill P.; Ensrud, Kristine E.; Fluharty, Laura; Gill, Thomas M.; Lewis, Cora E.; Pahor, Marco; Resnick, Susan M.; Storer, Thomas W.; Swerdloff, Ronald S.; Anton, Stephen; Basaria, Shehzad; Diem, Susan; Tabatabaie, Vafa; Hou, Xiaoling; Snyder, Peter J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 3, 01.03.2015, p. 1146-1155.

Research output: Contribution to journalArticle

Cunningham, GR, Stephens-Shields, AJ, Rosen, RC, Wang, C, Ellenberg, SS, Matsumoto, AM, Bhasin, S, Molitch, ME, Farrar, JT, Cella, D, Barrett-Connor, E, Cauley, JA, Cifelli, D, Crandall, JP, Ensrud, KE, Fluharty, L, Gill, TM, Lewis, CE, Pahor, M, Resnick, SM, Storer, TW, Swerdloff, RS, Anton, S, Basaria, S, Diem, S, Tabatabaie, V, Hou, X & Snyder, PJ 2015, 'Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 3, pp. 1146-1155. https://doi.org/10.1210/jc.2014-3818
Cunningham, Glenn R. ; Stephens-Shields, Alisa J. ; Rosen, Raymond C. ; Wang, Christina ; Ellenberg, Susan S. ; Matsumoto, Alvin M. ; Bhasin, Shalender ; Molitch, Mark E. ; Farrar, John T. ; Cella, David ; Barrett-Connor, Elizabeth ; Cauley, Jane A. ; Cifelli, Denise ; Crandall, Jill P. ; Ensrud, Kristine E. ; Fluharty, Laura ; Gill, Thomas M. ; Lewis, Cora E. ; Pahor, Marco ; Resnick, Susan M. ; Storer, Thomas W. ; Swerdloff, Ronald S. ; Anton, Stephen ; Basaria, Shehzad ; Diem, Susan ; Tabatabaie, Vafa ; Hou, Xiaoling ; Snyder, Peter J. / Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 3. pp. 1146-1155.
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abstract = "Context: The prevalence of sexual dysfunction, low vitality, and poor physical function increases with aging, as does the prevalence of low total and free testosterone (TT and FT) levels. However, the relationship between sex hormones and age-related alterations in older men is not clear. Objective: To test the hypotheses that baseline serum TT, FT, estradiol (E2), and sex hormone-binding globulin (SHBG) levels are independently associated with sexual function, vitality, and physical function in older symptomatic men with low testosterone levels participating in the Testosterone Trials (TTrials). Design: Cross-sectional study of baseline measures in the TTrials. Setting: The study was conducted at 12 sites in the United States. Participants: The 788 TTrials participants were ≥ 65 years and had evidence of sexual dysfunction, diminished vitality, and/or mobility disability, and an average of two TT < 275 ng/dL. Interventions: None. Main Outcome Measures: Question 4 of Psychosocial Daily Questionnaire (PDQ-Q4), the FACIT-Fatigue Scale, and the 6-minute walk test. Results: Baseline serum TT and FT, but not E2 or SHBG levels had small, but statistically significant associations with validated measures of sexual desire, erectile function, and sexual activity. None of these hormones was significantly associated within or across trials with FACIT-Fatigue, PHQ-9 Depression or Physical Function-10 scores, or gait speed. Conclusions: FT and TT levels were consistently, independently, and positively associated, albeit to a small degree, with measures of sexual desire, erectile function, and sexual activity, but not with measures of vitality or physical function in symptomatic older men with low T who qualified for the TTrials.",
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T1 - Association of sex hormones with sexual function, vitality, and physical function of symptomatic older men with low testosterone levels at baseline in the testosterone trials

AU - Cunningham, Glenn R.

AU - Stephens-Shields, Alisa J.

AU - Rosen, Raymond C.

AU - Wang, Christina

AU - Ellenberg, Susan S.

AU - Matsumoto, Alvin M.

AU - Bhasin, Shalender

AU - Molitch, Mark E.

AU - Farrar, John T.

AU - Cella, David

AU - Barrett-Connor, Elizabeth

AU - Cauley, Jane A.

AU - Cifelli, Denise

AU - Crandall, Jill P.

AU - Ensrud, Kristine E.

AU - Fluharty, Laura

AU - Gill, Thomas M.

AU - Lewis, Cora E.

AU - Pahor, Marco

AU - Resnick, Susan M.

AU - Storer, Thomas W.

AU - Swerdloff, Ronald S.

AU - Anton, Stephen

AU - Basaria, Shehzad

AU - Diem, Susan

AU - Tabatabaie, Vafa

AU - Hou, Xiaoling

AU - Snyder, Peter J.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Context: The prevalence of sexual dysfunction, low vitality, and poor physical function increases with aging, as does the prevalence of low total and free testosterone (TT and FT) levels. However, the relationship between sex hormones and age-related alterations in older men is not clear. Objective: To test the hypotheses that baseline serum TT, FT, estradiol (E2), and sex hormone-binding globulin (SHBG) levels are independently associated with sexual function, vitality, and physical function in older symptomatic men with low testosterone levels participating in the Testosterone Trials (TTrials). Design: Cross-sectional study of baseline measures in the TTrials. Setting: The study was conducted at 12 sites in the United States. Participants: The 788 TTrials participants were ≥ 65 years and had evidence of sexual dysfunction, diminished vitality, and/or mobility disability, and an average of two TT < 275 ng/dL. Interventions: None. Main Outcome Measures: Question 4 of Psychosocial Daily Questionnaire (PDQ-Q4), the FACIT-Fatigue Scale, and the 6-minute walk test. Results: Baseline serum TT and FT, but not E2 or SHBG levels had small, but statistically significant associations with validated measures of sexual desire, erectile function, and sexual activity. None of these hormones was significantly associated within or across trials with FACIT-Fatigue, PHQ-9 Depression or Physical Function-10 scores, or gait speed. Conclusions: FT and TT levels were consistently, independently, and positively associated, albeit to a small degree, with measures of sexual desire, erectile function, and sexual activity, but not with measures of vitality or physical function in symptomatic older men with low T who qualified for the TTrials.

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