Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population

Balazs Halmos, Ferenc Szalay, Tamas Cserniczky, Elemer Nemesanszky, Peter Lakatos, Stefan Barlage, Gerd Schmitz, Laszlo Romics, Albert Csaszar

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

We sought to determine the distribution of vitamin D receptor genotypes defined by the BsmI polymorphism and to investigate their association with bone mineral density in patients with primary biliary cirrhosis. Vitamin D receptor genotype and bone mineral density at the lumbar spine was determined in 31 female Hungarian patients with primary biliary cirrhosis and 51 age- matched healthy female controls. The genotype frequency (BB: 45%, Bb: 32%, bb: 22%) of the patients was significantly different from the control group (P = 0.01) due to an overrepresentation of the BB genotype. There was an apparent trend, not reaching statistical significance, for a lower bone mineral density in both the patient and control groups carrying a B allele. In conclusion, we found a strikingly high frequency of the BB genotype in patients with primary biliary cirrhosis, which raises questions about hormonal influences on the development of primary biliary cirrhosis.

Original languageEnglish (US)
Pages (from-to)1091-1095
Number of pages5
JournalDigestive Diseases and Sciences
Volume45
Issue number6
DOIs
StatePublished - Jul 6 2000
Externally publishedYes

Keywords

  • Autoimmunity
  • Bone mineral density
  • Genotypes
  • Primary biliary cirrhosis
  • Vitamin D receptor

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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    Halmos, B., Szalay, F., Cserniczky, T., Nemesanszky, E., Lakatos, P., Barlage, S., Schmitz, G., Romics, L., & Csaszar, A. (2000). Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population. Digestive Diseases and Sciences, 45(6), 1091-1095. https://doi.org/10.1023/A:1005581414918