Abstract
We sought to determine the distribution of vitamin D receptor genotypes defined by the BsmI polymorphism and to investigate their association with bone mineral density in patients with primary biliary cirrhosis. Vitamin D receptor genotype and bone mineral density at the lumbar spine was determined in 31 female Hungarian patients with primary biliary cirrhosis and 51 age- matched healthy female controls. The genotype frequency (BB: 45%, Bb: 32%, bb: 22%) of the patients was significantly different from the control group (P = 0.01) due to an overrepresentation of the BB genotype. There was an apparent trend, not reaching statistical significance, for a lower bone mineral density in both the patient and control groups carrying a B allele. In conclusion, we found a strikingly high frequency of the BB genotype in patients with primary biliary cirrhosis, which raises questions about hormonal influences on the development of primary biliary cirrhosis.
Original language | English (US) |
---|---|
Pages (from-to) | 1091-1095 |
Number of pages | 5 |
Journal | Digestive Diseases and Sciences |
Volume | 45 |
Issue number | 6 |
DOIs | |
State | Published - 2000 |
Externally published | Yes |
Keywords
- Autoimmunity
- Bone mineral density
- Genotypes
- Primary biliary cirrhosis
- Vitamin D receptor
ASJC Scopus subject areas
- Physiology
- Gastroenterology