Association of plasma soluble E-selectin and adiponectin with carotid plaque in patients with systemic lupus erythematosus

Harmony R. Reynolds, Jill Buyon, Mimi Kim, Tania L. Rivera, Peter Izmirly, Paul Tunick, Robert M. Clancy

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis but the mechanisms underlying this association are not understood. The role of endothelial dysfunction is hypothesized. Methods: In predominantly non-Caucasian patients with SLE (N= 119) and controls (N= 71), carotid ultrasonography was performed and circulating endothelial cells (CECs), soluble endothelial protein C receptor and gene polymorphism at A6936G, soluble E-selectin (sE-selectin), and adiponectin were assessed. Results: Carotid plaque was more prevalent among patients than controls (43% vs 17%, p= 0.0002). Mean CCA IMT was greater in patients compared to controls (0.59 ± 0.19. mm vs 0.54 ± 0.11. mm, p= 0.03). Among SLE patients, plaque was not associated with smoking, body-mass index, LDL, triglycerides, homocysteine, C-reactive protein, anti-ds DNA antibody, C3, C4, SLE activity, or medications. Age and levels of soluble E-selectin and adiponectin were significantly higher in the SLE patients with plaque compared to those without plaque in univariate and multivariate analyses. sE-selectin and adiponectin were found to serve as independent predictors of carotid plaque and that elevations were persistent over more than one visit. Unexpectedly, these biomarkers were present despite clinical quiescence. Conclusion: Premature atherosclerosis is a consistent feature of SLE and extends across ethnicities. Higher levels of adiponectin may represent a physiological attempt to limit further endothelial damage already reflected by the elevation in sE-selectin and the observed increase in plaque represents overwhelming of this reparative process by atherogenic stimuli.

Original languageEnglish (US)
Pages (from-to)569-574
Number of pages6
JournalAtherosclerosis
Volume210
Issue number2
DOIs
StatePublished - Jun 2010

Fingerprint

E-Selectin
Adiponectin
Systemic Lupus Erythematosus
Atherosclerosis
Antinuclear Antibodies
Homocysteine
Protein C
C-Reactive Protein
Ultrasonography
Body Mass Index
Multivariate Analysis
Endothelial Cells
Biomarkers
Smoking
DNA
Genes

Keywords

  • Adiponectin
  • Atherosclerosis
  • Carotid stenosis
  • E-selectin
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of plasma soluble E-selectin and adiponectin with carotid plaque in patients with systemic lupus erythematosus. / Reynolds, Harmony R.; Buyon, Jill; Kim, Mimi; Rivera, Tania L.; Izmirly, Peter; Tunick, Paul; Clancy, Robert M.

In: Atherosclerosis, Vol. 210, No. 2, 06.2010, p. 569-574.

Research output: Contribution to journalArticle

Reynolds, Harmony R. ; Buyon, Jill ; Kim, Mimi ; Rivera, Tania L. ; Izmirly, Peter ; Tunick, Paul ; Clancy, Robert M. / Association of plasma soluble E-selectin and adiponectin with carotid plaque in patients with systemic lupus erythematosus. In: Atherosclerosis. 2010 ; Vol. 210, No. 2. pp. 569-574.
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AU - Izmirly, Peter

AU - Tunick, Paul

AU - Clancy, Robert M.

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AB - Background: Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis but the mechanisms underlying this association are not understood. The role of endothelial dysfunction is hypothesized. Methods: In predominantly non-Caucasian patients with SLE (N= 119) and controls (N= 71), carotid ultrasonography was performed and circulating endothelial cells (CECs), soluble endothelial protein C receptor and gene polymorphism at A6936G, soluble E-selectin (sE-selectin), and adiponectin were assessed. Results: Carotid plaque was more prevalent among patients than controls (43% vs 17%, p= 0.0002). Mean CCA IMT was greater in patients compared to controls (0.59 ± 0.19. mm vs 0.54 ± 0.11. mm, p= 0.03). Among SLE patients, plaque was not associated with smoking, body-mass index, LDL, triglycerides, homocysteine, C-reactive protein, anti-ds DNA antibody, C3, C4, SLE activity, or medications. Age and levels of soluble E-selectin and adiponectin were significantly higher in the SLE patients with plaque compared to those without plaque in univariate and multivariate analyses. sE-selectin and adiponectin were found to serve as independent predictors of carotid plaque and that elevations were persistent over more than one visit. Unexpectedly, these biomarkers were present despite clinical quiescence. Conclusion: Premature atherosclerosis is a consistent feature of SLE and extends across ethnicities. Higher levels of adiponectin may represent a physiological attempt to limit further endothelial damage already reflected by the elevation in sE-selectin and the observed increase in plaque represents overwhelming of this reparative process by atherogenic stimuli.

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