TY - JOUR
T1 - Association of Normal-Weight Central Obesity with All-Cause and Cause-Specific Mortality among Postmenopausal Women
AU - Sun, Yangbo
AU - Liu, Buyun
AU - Snetselaar, Linda G.
AU - Wallace, Robert B.
AU - Caan, Bette J.
AU - Rohan, Thomas E.
AU - Neuhouser, Marian L.
AU - Shadyab, Aladdin H.
AU - Chlebowski, Rowan T.
AU - Manson, Joann E.
AU - Bao, Wei
N1 - Funding Information:
Supervision: Snetselaar, Caan, Neuhouser, Chlebowski, Bao. Other: Shadyab. Conflict of Interest Disclosures: Dr Chlebowski reported receiving grants through the National Institutes of Health, National Cancer Institute, and American Institute of Cancer Research during the conduct of this study and receiving personal fees from Novartis, AstraZeneca, Genentech, Amgen, Genomic Health, and Immunomedics outside the submitted work. Dr Manson reported grants from the National Institutes of Health during the conduct of the study and outside the submitted work. No other disclosures were reported.
Funding Information:
Funding/Support: The Women’s Health Initiative (WHI) program is funded through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C from the National Heart, Lung, and Blood Institute, the National Institutes of Health, and the US Department of Health and Human Services.
Publisher Copyright:
© 2019. All rights reserved.
PY - 2019/7/26
Y1 - 2019/7/26
N2 - Importance: Current public health guidelines for obesity prevention and control focus on promoting a normal body mass index (BMI), rarely addressing central obesity, which is reflected by high waist circumference (WC) and common in the general population. Studies of the association of normal-weight central obesity with long-term health outcomes are sparse. Objective: To examine associations of normal-weight central obesity with all-cause and cause-specific mortality in postmenopausal women in the United States. Design, Setting, and Participants: A nationwide prospective cohort study of 156624 postmenopausal women enrolled in the Women's Health Initiative at 40 clinical centers in the United States between 1993 and 1998. These women were observed through February 2017. Data analysis was performed from September 15, 2017, to March 13, 2019. Exposures: Different combinations of BMI (calculated as weight in kilograms divided by height in meters squared; normal weight: BMI, 18.5-24.9; overweight: BMI, 25.0-29.9; and obesity: BMI, ≥30) and WC (normal: WC, ≤88 cm and high: WC, >88 cm). Main Outcomes and Measures: Mortality from all causes, cardiovascular disease, and cancer. Results: Of the 156624 women (mean [SD] age, 63.2 [7.2] years), during 2811187 person-years of follow-up, 43838 deaths occurred, including 12965 deaths from cardiovascular disease (29.6%) and 11828 deaths from cancer (27.0%). Compared with women with normal weight and no central obesity and adjusted for demographic characteristics, socioeconomic status, lifestyle factors, and hormone use, the hazard ratio for all-cause mortality was 1.31 (95% CI, 1.20-1.42) among women with normal weight and central obesity, 0.91 (95% CI, 0.89-0.94) among women with overweight and no central obesity, 1.16 (95% CI, 1.13-1.20) for women with overweight and central obesity, 0.93 (95% CI, 0.89-0.94) for women with obesity and no central obesity, and 1.30 (95% CI, 1.27-1.34) for women with obesity and central obesity. Compared with normal weight without central obesity, normal-weight central obesity was associated with higher risk of cardiovascular disease mortality (hazard ratio, 1.25; 95% CI, 1.05-1.46) and cancer mortality (hazard ratio, 1.20; 95% CI, 1.01-1.43). Conclusions and Relevance: Normal-weight central obesity in women was associated with excess risk of mortality, similar to that of women with BMI-defined obesity with central obesity. These findings underscore the need for future public health guidelines to include the prevention and control of central obesity, even in individuals with normal BMI..
AB - Importance: Current public health guidelines for obesity prevention and control focus on promoting a normal body mass index (BMI), rarely addressing central obesity, which is reflected by high waist circumference (WC) and common in the general population. Studies of the association of normal-weight central obesity with long-term health outcomes are sparse. Objective: To examine associations of normal-weight central obesity with all-cause and cause-specific mortality in postmenopausal women in the United States. Design, Setting, and Participants: A nationwide prospective cohort study of 156624 postmenopausal women enrolled in the Women's Health Initiative at 40 clinical centers in the United States between 1993 and 1998. These women were observed through February 2017. Data analysis was performed from September 15, 2017, to March 13, 2019. Exposures: Different combinations of BMI (calculated as weight in kilograms divided by height in meters squared; normal weight: BMI, 18.5-24.9; overweight: BMI, 25.0-29.9; and obesity: BMI, ≥30) and WC (normal: WC, ≤88 cm and high: WC, >88 cm). Main Outcomes and Measures: Mortality from all causes, cardiovascular disease, and cancer. Results: Of the 156624 women (mean [SD] age, 63.2 [7.2] years), during 2811187 person-years of follow-up, 43838 deaths occurred, including 12965 deaths from cardiovascular disease (29.6%) and 11828 deaths from cancer (27.0%). Compared with women with normal weight and no central obesity and adjusted for demographic characteristics, socioeconomic status, lifestyle factors, and hormone use, the hazard ratio for all-cause mortality was 1.31 (95% CI, 1.20-1.42) among women with normal weight and central obesity, 0.91 (95% CI, 0.89-0.94) among women with overweight and no central obesity, 1.16 (95% CI, 1.13-1.20) for women with overweight and central obesity, 0.93 (95% CI, 0.89-0.94) for women with obesity and no central obesity, and 1.30 (95% CI, 1.27-1.34) for women with obesity and central obesity. Compared with normal weight without central obesity, normal-weight central obesity was associated with higher risk of cardiovascular disease mortality (hazard ratio, 1.25; 95% CI, 1.05-1.46) and cancer mortality (hazard ratio, 1.20; 95% CI, 1.01-1.43). Conclusions and Relevance: Normal-weight central obesity in women was associated with excess risk of mortality, similar to that of women with BMI-defined obesity with central obesity. These findings underscore the need for future public health guidelines to include the prevention and control of central obesity, even in individuals with normal BMI..
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U2 - 10.1001/jamanetworkopen.2019.7337
DO - 10.1001/jamanetworkopen.2019.7337
M3 - Article
C2 - 31339542
AN - SCOPUS:85069840486
VL - 2
JO - JAMA network open
JF - JAMA network open
SN - 2574-3805
IS - 7
M1 - 7337
ER -