Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging

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Abstract

Conclusion: Our findings provide evidence that variation in late-life decline in physical function is associated with familial longevity, and may vary for men and women.

Background: Although many genetic and nongenetic factors interact to determine an individual's physical phenotype, there has been limited examination of the contribution of family history of exceptional parental longevity on decline in physical function in aging.

Methods: The LonGenity study recruited a relatively genetically homogenous cohort of Ashkenazi Jewish adults age 65 and older, who were defined as either offspring of parents with exceptional longevity ([OPEL]: having at least one parent who lived to age 95 or older) or offspring of parents with usual survival ([OPUS]: neither parent survived to age 95). Decline in performance on objective measures of strength (grip strength), balance (unipedal stance), and mobility (gait speed) as well as a composite physical function measure, the Short physical performance battery (SPPB), were compared between the two groups over a median follow-up of 3.2 years, accounting for age, sex, education, and comorbidities.

Results: Of the 984 LonGenity participants (mean age 76, 55% women), 448 were OPEL and 536 were OPUS. Compared to OPUS, OPEL had slower decline on measures of unipedal stance (-0.03 log-units/year, p = .026), repeated chair rise (0.13 s/year, p = .020) and SPPB (-0.11 points/year, p = .002). OPEL women had slower decline on chair rise and SPPB scores compared to OPUS women, although OPEL men had slower decline on unipedal stance compared to OPUS men.

Original languageEnglish (US)
Pages (from-to)1649-1655
Number of pages7
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume72
Issue number12
DOIs
StatePublished - Nov 9 2017

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Parents
Survival
Sex Education
Hand Strength
Comorbidity
Phenotype

Keywords

  • Genotypes
  • Phenotypes
  • Physical function
  • Successful aging

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

@article{95b8375f31c8478abed2da2ab9ab2629,
title = "Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging",
abstract = "Conclusion: Our findings provide evidence that variation in late-life decline in physical function is associated with familial longevity, and may vary for men and women.Background: Although many genetic and nongenetic factors interact to determine an individual's physical phenotype, there has been limited examination of the contribution of family history of exceptional parental longevity on decline in physical function in aging.Methods: The LonGenity study recruited a relatively genetically homogenous cohort of Ashkenazi Jewish adults age 65 and older, who were defined as either offspring of parents with exceptional longevity ([OPEL]: having at least one parent who lived to age 95 or older) or offspring of parents with usual survival ([OPUS]: neither parent survived to age 95). Decline in performance on objective measures of strength (grip strength), balance (unipedal stance), and mobility (gait speed) as well as a composite physical function measure, the Short physical performance battery (SPPB), were compared between the two groups over a median follow-up of 3.2 years, accounting for age, sex, education, and comorbidities.Results: Of the 984 LonGenity participants (mean age 76, 55{\%} women), 448 were OPEL and 536 were OPUS. Compared to OPUS, OPEL had slower decline on measures of unipedal stance (-0.03 log-units/year, p = .026), repeated chair rise (0.13 s/year, p = .020) and SPPB (-0.11 points/year, p = .002). OPEL women had slower decline on chair rise and SPPB scores compared to OPUS women, although OPEL men had slower decline on unipedal stance compared to OPUS men.",
keywords = "Genotypes, Phenotypes, Physical function, Successful aging",
author = "Ayers, {Emmeline I.} and Nir Barzilai and Crandall, {Jill P.} and Sofiya Milman and Joe Verghese",
year = "2017",
month = "11",
day = "9",
doi = "10.1093/gerona/glx053",
language = "English (US)",
volume = "72",
pages = "1649--1655",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "12",

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TY - JOUR

T1 - Association of Family History of Exceptional Longevity With Decline in Physical Function in Aging

AU - Ayers, Emmeline I.

AU - Barzilai, Nir

AU - Crandall, Jill P.

AU - Milman, Sofiya

AU - Verghese, Joe

PY - 2017/11/9

Y1 - 2017/11/9

N2 - Conclusion: Our findings provide evidence that variation in late-life decline in physical function is associated with familial longevity, and may vary for men and women.Background: Although many genetic and nongenetic factors interact to determine an individual's physical phenotype, there has been limited examination of the contribution of family history of exceptional parental longevity on decline in physical function in aging.Methods: The LonGenity study recruited a relatively genetically homogenous cohort of Ashkenazi Jewish adults age 65 and older, who were defined as either offspring of parents with exceptional longevity ([OPEL]: having at least one parent who lived to age 95 or older) or offspring of parents with usual survival ([OPUS]: neither parent survived to age 95). Decline in performance on objective measures of strength (grip strength), balance (unipedal stance), and mobility (gait speed) as well as a composite physical function measure, the Short physical performance battery (SPPB), were compared between the two groups over a median follow-up of 3.2 years, accounting for age, sex, education, and comorbidities.Results: Of the 984 LonGenity participants (mean age 76, 55% women), 448 were OPEL and 536 were OPUS. Compared to OPUS, OPEL had slower decline on measures of unipedal stance (-0.03 log-units/year, p = .026), repeated chair rise (0.13 s/year, p = .020) and SPPB (-0.11 points/year, p = .002). OPEL women had slower decline on chair rise and SPPB scores compared to OPUS women, although OPEL men had slower decline on unipedal stance compared to OPUS men.

AB - Conclusion: Our findings provide evidence that variation in late-life decline in physical function is associated with familial longevity, and may vary for men and women.Background: Although many genetic and nongenetic factors interact to determine an individual's physical phenotype, there has been limited examination of the contribution of family history of exceptional parental longevity on decline in physical function in aging.Methods: The LonGenity study recruited a relatively genetically homogenous cohort of Ashkenazi Jewish adults age 65 and older, who were defined as either offspring of parents with exceptional longevity ([OPEL]: having at least one parent who lived to age 95 or older) or offspring of parents with usual survival ([OPUS]: neither parent survived to age 95). Decline in performance on objective measures of strength (grip strength), balance (unipedal stance), and mobility (gait speed) as well as a composite physical function measure, the Short physical performance battery (SPPB), were compared between the two groups over a median follow-up of 3.2 years, accounting for age, sex, education, and comorbidities.Results: Of the 984 LonGenity participants (mean age 76, 55% women), 448 were OPEL and 536 were OPUS. Compared to OPUS, OPEL had slower decline on measures of unipedal stance (-0.03 log-units/year, p = .026), repeated chair rise (0.13 s/year, p = .020) and SPPB (-0.11 points/year, p = .002). OPEL women had slower decline on chair rise and SPPB scores compared to OPUS women, although OPEL men had slower decline on unipedal stance compared to OPUS men.

KW - Genotypes

KW - Phenotypes

KW - Physical function

KW - Successful aging

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U2 - 10.1093/gerona/glx053

DO - 10.1093/gerona/glx053

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JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 12

ER -