Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer

Michael Fattouh; Gina Y. Chang; Thomas J. Ow; Keivan Shifteh; Gregory Rosenblatt; Viraj M. Patel; Richard V. Smith; Michael B. Prystowsky; Nicolas F. Schlecht

doi:10.1002/hed.25420

Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer

Michael Fattouh, Gina Y. Chang, Thomas J. Ow, Keivan Shifteh, Gregory Rosenblatt, Viraj M. Patel, Richard V. Smith, Michael B. Prystowsky, Nicolas F. Schlecht

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.

Original language	English (US)
Pages (from-to)	707-714
Number of pages	8
Journal	Head and Neck
Volume	41
Issue number	3
DOIs	https://doi.org/10.1002/hed.25420
State	Published - Mar 1 2019

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Keywords

body mass index
epidemiology
obesity
sarcopenia
survival

ASJC Scopus subject areas

Otorhinolaryngology

Cite this

Fattouh, M., Chang, G. Y., Ow, T. J., Shifteh, K., Rosenblatt, G., Patel, V. M., Smith, R. V., Prystowsky, M. B., & Schlecht, N. F. (2019). Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer. Head and Neck, 41(3), 707-714. https://doi.org/10.1002/hed.25420

Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer. / Fattouh, Michael; Chang, Gina Y.; Ow, Thomas J.; Shifteh, Keivan; Rosenblatt, Gregory; Patel, Viraj M.; Smith, Richard V.; Prystowsky, Michael B.; Schlecht, Nicolas F.

In: Head and Neck, Vol. 41, No. 3, 01.03.2019, p. 707-714.

Research output: Contribution to journal › Article

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abstract = "Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.",

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10.1002/hed.25420