@article{64bc2486bd8f4f8ebd47483028d21138,
title = "Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer",
abstract = "Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.",
keywords = "body mass index, epidemiology, obesity, sarcopenia, survival",
author = "Michael Fattouh and Chang, {Gina Y.} and Ow, {Thomas J.} and Keivan Shifteh and Gregory Rosenblatt and Patel, {Viraj M.} and Smith, {Richard V.} and Prystowsky, {Michael B.} and Schlecht, {Nicolas F.}",
note = "Funding Information: This project is supported in part by NIH grants CA115243 and DE023941 (to Nicolas F. Schlecht), National Cancer Institute P30 grants to the Einstein Cancer Research Center (CA013330) and to Roswell Park Comprehensive Cancer Institute (CA016056), and the Departments of Otorhinolaryngology-Head & Neck Surgery, Radiology and Pathology, Albert Einstein College of Medicine, Montefiore Medical Center. Thomas J. Ow's contribution was supported by a NIH K12 grant (CA132783) and a National Center for Advancing Translational Science (NCATS) grant (UL1TR001073; to the Einstein-Montefiore CTSA). Funding Information: information National Institutes of Health, Grant/Award Number: CA013330CA016056CA115243 CA132783DE023941 UL1TR001073; Albert Einstein College of Medicine; National Cancer InstituteThis project is supported in part by NIH grants CA115243 and DE023941 (to Nicolas F. Schlecht), National Cancer Institute P30 grants to the Einstein Cancer Research Center (CA013330) and to Roswell Park Comprehensive Cancer Institute (CA016056), and the Departments of Otorhinolaryngology-Head & Neck Surgery, Radiology and Pathology, Albert Einstein College of Medicine, Montefiore Medical Center. Thomas J. Ow's contribution was supported by a NIH K12 grant (CA132783) and a National Center for Advancing Translational Science (NCATS) grant (UL1TR001073; to the Einstein-Montefiore CTSA). Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2019",
month = mar,
day = "1",
doi = "10.1002/hed.25420",
language = "English (US)",
volume = "41",
pages = "707--714",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "Wiley-Liss Inc.",
number = "3",
}
