Abstract
Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.
| Original language | English (US) |
|---|---|
| Journal | Head and Neck |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- body mass index
- epidemiology
- obesity
- sarcopenia
- survival
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer. / Fattouh, Michael; Chang, Gina Y.; Ow, Thomas J.; Shifteh, Keivan; Rosenblatt, Gregory; Patel, Viraj M.; Smith, Richard V.; Prystowsky, Michael B.; Schlecht, Nicolas F.
In: Head and Neck, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer
AU - Fattouh, Michael
AU - Chang, Gina Y.
AU - Ow, Thomas J.
AU - Shifteh, Keivan
AU - Rosenblatt, Gregory
AU - Patel, Viraj M.
AU - Smith, Richard V.
AU - Prystowsky, Michael B.
AU - Schlecht, Nicolas F.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.
AB - Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.
KW - body mass index
KW - epidemiology
KW - obesity
KW - sarcopenia
KW - survival
UR - http://www.scopus.com/inward/record.url?scp=85058996974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058996974&partnerID=8YFLogxK
U2 - 10.1002/hed.25420
DO - 10.1002/hed.25420
M3 - Article
C2 - 30582237
AN - SCOPUS:85058996974
JO - Head and Neck
JF - Head and Neck
SN - 1043-3074
ER -