Association between essential tremor and blood lead concentration

Elan D. Louis, Eva C. Jurewicz, Lakeisha Applegate, Pam Factor-Litvak, Michael K. Parides, Leslie Andrews, Vesna Slavkovich, Joseph K. Graziano, Spencer Carroll, Andrew Todd

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Lead is a ubiquitous toxicant that causes tremor and cerebellar damage. Essential tremor (ET) is a highly prevalent neurologic disease associated with cerebellar involvement. Although environmental toxicants may play a role in ET etiology and their identification is a critical step in disease prevention, these toxicants have received little attention. Our objective was to test the hypothesis that ET is associated with lead exposure. Therefore, blood lead (BPb) concentrations were measured and a lifetime occupational history was assessed in ET patients and in controls. We frequency matched 100 ET patients and 143 controls on age, sex, and ethnicity. BPb concentrations were analyzed using graphite furnace atomic absorption spectrophotometry. A lifetime occupational history was reviewed by an industrial hygienist. BPb concentrations were higher in ET patients than in controls (mean ± SD, 3.3 ± 2.4 and 2.6 ± 1.6 μg/dL, respectively; median, 2.7 and 2.3 μg/dL; p = 0.038). In a logistic regression model, BPb concentration was associated with diagnosis [control vs. ET patient, odds ratio (OR) per unit increase = 1.21; 95% confidence interval (CI), 1.05-1.39; p = 0.007]. BPb concentration was associated with diagnosis (OR per unit increase = 1.19; 95% CI, 1.03-1.37; p = 0.02) after adjusting for potential confounders. Prevalence of lifetime occupational lead exposure was similar in ET patients and controls. We report an association between BPb concentration and ET. Determining whether this association is due to increased exposure to lead or a difference in lead kinetics in ET patients requires further investigation.

Original languageEnglish (US)
Pages (from-to)1707-1711
Number of pages5
JournalEnvironmental Health Perspectives
Volume111
Issue number14
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

Essential Tremor
Logistic Models
Odds Ratio
Lead
Confidence Intervals
Atomic Spectrophotometry
Graphite
Tremor
Occupational Exposure
Nervous System Diseases

Keywords

  • Epidemiology
  • Essential tremor
  • Etiology
  • Lead
  • Occupational exposure

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Louis, E. D., Jurewicz, E. C., Applegate, L., Factor-Litvak, P., Parides, M. K., Andrews, L., ... Todd, A. (2003). Association between essential tremor and blood lead concentration. Environmental Health Perspectives, 111(14), 1707-1711. https://doi.org/10.1289/ehp.6404

Association between essential tremor and blood lead concentration. / Louis, Elan D.; Jurewicz, Eva C.; Applegate, Lakeisha; Factor-Litvak, Pam; Parides, Michael K.; Andrews, Leslie; Slavkovich, Vesna; Graziano, Joseph K.; Carroll, Spencer; Todd, Andrew.

In: Environmental Health Perspectives, Vol. 111, No. 14, 01.01.2003, p. 1707-1711.

Research output: Contribution to journalArticle

Louis, ED, Jurewicz, EC, Applegate, L, Factor-Litvak, P, Parides, MK, Andrews, L, Slavkovich, V, Graziano, JK, Carroll, S & Todd, A 2003, 'Association between essential tremor and blood lead concentration', Environmental Health Perspectives, vol. 111, no. 14, pp. 1707-1711. https://doi.org/10.1289/ehp.6404
Louis ED, Jurewicz EC, Applegate L, Factor-Litvak P, Parides MK, Andrews L et al. Association between essential tremor and blood lead concentration. Environmental Health Perspectives. 2003 Jan 1;111(14):1707-1711. https://doi.org/10.1289/ehp.6404
Louis, Elan D. ; Jurewicz, Eva C. ; Applegate, Lakeisha ; Factor-Litvak, Pam ; Parides, Michael K. ; Andrews, Leslie ; Slavkovich, Vesna ; Graziano, Joseph K. ; Carroll, Spencer ; Todd, Andrew. / Association between essential tremor and blood lead concentration. In: Environmental Health Perspectives. 2003 ; Vol. 111, No. 14. pp. 1707-1711.
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