TY - JOUR
T1 - Association between dietary inflammatory potential and breast cancer incidence and death
T2 - Results from the Women's Health Initiative
AU - Tabung, Fred K.
AU - Steck, Susan E.
AU - Liese, Angela D.
AU - Zhang, Jiajia
AU - Ma, Yunsheng
AU - Caan, Bette
AU - Chlebowski, Rowan T.
AU - Freudenheim, Jo L.
AU - Hou, Lifang
AU - Mossavar-Rahmani, Yasmin
AU - Shivappa, Nitin
AU - Vitolins, Mara Z.
AU - Wactawski-Wende, Jean
AU - Ockene, Judith K.
AU - Hébert, James R.
N1 - Publisher Copyright:
© 2016 Cancer Research UK.
PY - 2016/5/24
Y1 - 2016/5/24
N2 - Background: Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death.Methods:The DII was calculated from a baseline food frequency questionnaire in 122 788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 years, there were 7495 breast cancer cases and 667 breast cancer deaths. We used Cox regression to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by DII quintiles (Q) for incidence of overall breast cancer, breast cancer subtypes, and deaths from breast cancer. The lowest quintile (representing the most anti-inflammatory diet) was the reference.Results:The DII was not associated with incidence of overall breast cancer (HR Q5vsQ1, 0.99; 95% CI, 0.91-1.07; P trend =0.83 for overall breast cancer). In a full cohort analysis, a higher risk of death from breast cancer was associated with consumption of more pro-inflammatory diets at baseline, after controlling for multiple potential confounders (HR Q5vsQ1, 1.33; 95% CI, 1.01-1.76; P trend =0.03).Conclusions:Future studies are needed to examine the inflammatory potential of post-diagnosis diet given the suggestion from the current study that dietary inflammatory potential before diagnosis is related to breast cancer death.
AB - Background: Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death.Methods:The DII was calculated from a baseline food frequency questionnaire in 122 788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 years, there were 7495 breast cancer cases and 667 breast cancer deaths. We used Cox regression to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by DII quintiles (Q) for incidence of overall breast cancer, breast cancer subtypes, and deaths from breast cancer. The lowest quintile (representing the most anti-inflammatory diet) was the reference.Results:The DII was not associated with incidence of overall breast cancer (HR Q5vsQ1, 0.99; 95% CI, 0.91-1.07; P trend =0.83 for overall breast cancer). In a full cohort analysis, a higher risk of death from breast cancer was associated with consumption of more pro-inflammatory diets at baseline, after controlling for multiple potential confounders (HR Q5vsQ1, 1.33; 95% CI, 1.01-1.76; P trend =0.03).Conclusions:Future studies are needed to examine the inflammatory potential of post-diagnosis diet given the suggestion from the current study that dietary inflammatory potential before diagnosis is related to breast cancer death.
KW - Women's Health Initiative
KW - breast cancer
KW - dietary inflammatory index
KW - incidence
KW - mortality
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U2 - 10.1038/bjc.2016.98
DO - 10.1038/bjc.2016.98
M3 - Article
C2 - 27100730
AN - SCOPUS:84964350815
SN - 0007-0920
VL - 114
SP - 1277
EP - 1285
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 11
ER -