Association between cigarette smoking and colorectal cancer in the Women's Health Initiative

Electra D. Paskett, Katherine W. Reeves, Thomas E. Rohan, Matthew A. Allison, Carla D. Williams, Catherine R. Messina, Evelyn Whitlock, Alicia Sato, Julie R. Hunt

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Abstract

The evidence linking cigarette smoking to the risk of colorectal cancer is inconsistent. We investigated the associations between active and passive smoking and colorectal cancer among 146877 Women's Health Initiative participants. Women reported detailed smoking histories at enrollment. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for the association between smoking and overall and site-specific risk of colorectal cancer. Invasive colorectal cancer was diagnosed in 1242 women over an average of 7.8 years (range = 0.003-11.2 years) of follow-up. In adjusted analyses, statistically significant positive associations were observed between most measures of cigarette smoking and risk of invasive colorectal cancer. Site-specific analyses indicated that current smokers had a statistically significantly increased risk of rectal cancer (HR = 1.95, 95% CI = 1.10 to 3.47) but not colon cancer (HR = 1.03, 95% CI = 0.77 to 1.38), compared with never smokers. Passive smoke exposure was not associated with colorectal cancer in adjusted analyses. Thus, active exposure to cigarette smoking appears to be a risk factor for rectal cancer.

Original languageEnglish (US)
Pages (from-to)1729-1735
Number of pages7
JournalJournal of the National Cancer Institute
Volume99
Issue number22
DOIs
StatePublished - Nov 2007

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Women's Health
Colorectal Neoplasms
Smoking
Confidence Intervals
Rectal Neoplasms
Tobacco Smoke Pollution
Smoke
Colonic Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Paskett, E. D., Reeves, K. W., Rohan, T. E., Allison, M. A., Williams, C. D., Messina, C. R., ... Hunt, J. R. (2007). Association between cigarette smoking and colorectal cancer in the Women's Health Initiative. Journal of the National Cancer Institute, 99(22), 1729-1735. https://doi.org/10.1093/jnci/djm176

Association between cigarette smoking and colorectal cancer in the Women's Health Initiative. / Paskett, Electra D.; Reeves, Katherine W.; Rohan, Thomas E.; Allison, Matthew A.; Williams, Carla D.; Messina, Catherine R.; Whitlock, Evelyn; Sato, Alicia; Hunt, Julie R.

In: Journal of the National Cancer Institute, Vol. 99, No. 22, 11.2007, p. 1729-1735.

Research output: Contribution to journalArticle

Paskett, ED, Reeves, KW, Rohan, TE, Allison, MA, Williams, CD, Messina, CR, Whitlock, E, Sato, A & Hunt, JR 2007, 'Association between cigarette smoking and colorectal cancer in the Women's Health Initiative', Journal of the National Cancer Institute, vol. 99, no. 22, pp. 1729-1735. https://doi.org/10.1093/jnci/djm176
Paskett, Electra D. ; Reeves, Katherine W. ; Rohan, Thomas E. ; Allison, Matthew A. ; Williams, Carla D. ; Messina, Catherine R. ; Whitlock, Evelyn ; Sato, Alicia ; Hunt, Julie R. / Association between cigarette smoking and colorectal cancer in the Women's Health Initiative. In: Journal of the National Cancer Institute. 2007 ; Vol. 99, No. 22. pp. 1729-1735.
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