Assessment of worldwide acute kidney injury epidemiology in neonates: Design of a retrospective cohort study

Neonatal Kidney Collaborative

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Introduction: Acute kidney injury (AKI) affects ~30% of hospitalized neonates. Critical to advancing our understanding of neonatal AKI is collaborative research among neonatologists and nephrologists. The Neonatal Kidney Collaborative (NKC) is an international, multidisciplinary group dedicated to investigating neonatal AKI. The AWAKEN study (Assessment of Worldwide Acute Kidney injury Epidemiology in Neonates) was designed to describe the epidemiology of neonatal AKI, validate the definition of neonatal AKI, identify primary risk factors for neonatal AKI, and investigate the contribution of fluid management to AKI events and short-term outcomes. Methods and analysis: The NKC was established with at least one pediatric nephrologist and neonatologist from 24 institutions in 4 countries (USA, Canada, Australia, and India). A Steering Committee and four subcommittees were created. The database subcommittee oversaw the development of the web-based database (MediData Rave™) that captured all NICU admissions from 1/1/14 to 3/31/14. Inclusion and exclusion criteria were applied to eliminate neonates with a low likelihood of AKI. Data collection included: (1) baseline demographic information; (2) daily physiologic parameters and care received during the first week of life; (3) weekly "snapshots"; (4) discharge information including growth parameters, final diagnoses, discharge medications, and need for renal replacement therapy; and (5) all serum creatinine values. Ethics and dissemination: AWAKEN was proposed as human subjects research. The study design allowed for a waiver of informed consent/parental permission. NKC investigators will disseminate data through peer-reviewed publications and educational conferences. Discussion: The purpose of this publication is to describe the formation of the NKC, the establishment of the AWAKEN cohort and database, future directions, and a few "lessons learned." The AWAKEN database includes ~325 unique variables and > 4 million discrete data points. AWAKEN will be the largest, most inclusive neonatal AKI study to date. In addition to validating the neonatal AKI definition and identifying risk factors for AKI, this study will uncover variations in practice patterns related to fluid provision, renal function monitoring, and involvement of pediatric nephrologists during hospitalization. The AWAKEN study will position the NKC to achieve the long-term goal of improving the lives, health, and well-being of newborns at risk for kidney disease.

Original languageEnglish (US)
Article number68
JournalFrontiers in Pediatrics
Volume4
Issue numberJUL
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Fingerprint

Acute Kidney Injury
Epidemiology
Cohort Studies
Retrospective Studies
Newborn Infant
Kidney
Databases
Pediatrics
Renal Replacement Therapy
Kidney Diseases
Informed Consent
Research
Ethics
Canada
Publications
India
Creatinine
Hospitalization
Research Personnel
Demography

Keywords

  • Acute renal failure
  • AWAKEN
  • Database
  • KDIGO
  • Neonate
  • NKC

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Assessment of worldwide acute kidney injury epidemiology in neonates : Design of a retrospective cohort study. / Neonatal Kidney Collaborative.

In: Frontiers in Pediatrics, Vol. 4, No. JUL, 68, 01.07.2016.

Research output: Contribution to journalArticle

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author = "{Neonatal Kidney Collaborative} and Jetton, {Jennifer G.} and Ronnie Guillet and Askenazi, {David J.} and Lynn Dill and Judd Jacobs and Kent, {Alison L.} and Selewski, {David T.} and Abitbol, {Carolyn L.} and Kaskel, {Frederick J.} and Mhanna, {Maroun J.} and Namasivayam Ambalavanan and Charlton, {Jennifer R.} and Arikan, {Ayse Akcan} and Alok Bhutada and Elizabeth Bonachea and Louis Boohaker and Brophy, {Patrick D.} and Chishti, {Aftab S.} and Colaizy, {Tarah T.} and Cole, {F. Sessions} and Carl D'Angio and Davis, {T. Keefe} and Marissa DeFreitas and Joshua Dower and Shahnaz Duara and Jeffery Fletcher and Mamta Fuloria and Jason Gien and Gist, {Katja M.} and Goldstein, {Stuart L.} and Russell Griffin and Hanna, {Mina H.} and Sangeeta Hingorani and Susan Ingraham and Catherine Joseph and Surender Khokhar and Klein, {Jonathan M.} and Deepak Kumar and Kupferman, {Juan C.} and John Mahan and Cherry Mammen and Ayesa Mian and Lawrence Milner and Arwa Nada and Nathan, {Amy T.} and Robin Ohls and Sofia Perazzo and Erin Rademacher and Rupesh Raina and Reidy, {Kimberly J.}",
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T1 - Assessment of worldwide acute kidney injury epidemiology in neonates

T2 - Design of a retrospective cohort study

AU - Neonatal Kidney Collaborative

AU - Jetton, Jennifer G.

AU - Guillet, Ronnie

AU - Askenazi, David J.

AU - Dill, Lynn

AU - Jacobs, Judd

AU - Kent, Alison L.

AU - Selewski, David T.

AU - Abitbol, Carolyn L.

AU - Kaskel, Frederick J.

AU - Mhanna, Maroun J.

AU - Ambalavanan, Namasivayam

AU - Charlton, Jennifer R.

AU - Arikan, Ayse Akcan

AU - Bhutada, Alok

AU - Bonachea, Elizabeth

AU - Boohaker, Louis

AU - Brophy, Patrick D.

AU - Chishti, Aftab S.

AU - Colaizy, Tarah T.

AU - Cole, F. Sessions

AU - D'Angio, Carl

AU - Davis, T. Keefe

AU - DeFreitas, Marissa

AU - Dower, Joshua

AU - Duara, Shahnaz

AU - Fletcher, Jeffery

AU - Fuloria, Mamta

AU - Gien, Jason

AU - Gist, Katja M.

AU - Goldstein, Stuart L.

AU - Griffin, Russell

AU - Hanna, Mina H.

AU - Hingorani, Sangeeta

AU - Ingraham, Susan

AU - Joseph, Catherine

AU - Khokhar, Surender

AU - Klein, Jonathan M.

AU - Kumar, Deepak

AU - Kupferman, Juan C.

AU - Mahan, John

AU - Mammen, Cherry

AU - Mian, Ayesa

AU - Milner, Lawrence

AU - Nada, Arwa

AU - Nathan, Amy T.

AU - Ohls, Robin

AU - Perazzo, Sofia

AU - Rademacher, Erin

AU - Raina, Rupesh

AU - Reidy, Kimberly J.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Introduction: Acute kidney injury (AKI) affects ~30% of hospitalized neonates. Critical to advancing our understanding of neonatal AKI is collaborative research among neonatologists and nephrologists. The Neonatal Kidney Collaborative (NKC) is an international, multidisciplinary group dedicated to investigating neonatal AKI. The AWAKEN study (Assessment of Worldwide Acute Kidney injury Epidemiology in Neonates) was designed to describe the epidemiology of neonatal AKI, validate the definition of neonatal AKI, identify primary risk factors for neonatal AKI, and investigate the contribution of fluid management to AKI events and short-term outcomes. Methods and analysis: The NKC was established with at least one pediatric nephrologist and neonatologist from 24 institutions in 4 countries (USA, Canada, Australia, and India). A Steering Committee and four subcommittees were created. The database subcommittee oversaw the development of the web-based database (MediData Rave™) that captured all NICU admissions from 1/1/14 to 3/31/14. Inclusion and exclusion criteria were applied to eliminate neonates with a low likelihood of AKI. Data collection included: (1) baseline demographic information; (2) daily physiologic parameters and care received during the first week of life; (3) weekly "snapshots"; (4) discharge information including growth parameters, final diagnoses, discharge medications, and need for renal replacement therapy; and (5) all serum creatinine values. Ethics and dissemination: AWAKEN was proposed as human subjects research. The study design allowed for a waiver of informed consent/parental permission. NKC investigators will disseminate data through peer-reviewed publications and educational conferences. Discussion: The purpose of this publication is to describe the formation of the NKC, the establishment of the AWAKEN cohort and database, future directions, and a few "lessons learned." The AWAKEN database includes ~325 unique variables and > 4 million discrete data points. AWAKEN will be the largest, most inclusive neonatal AKI study to date. In addition to validating the neonatal AKI definition and identifying risk factors for AKI, this study will uncover variations in practice patterns related to fluid provision, renal function monitoring, and involvement of pediatric nephrologists during hospitalization. The AWAKEN study will position the NKC to achieve the long-term goal of improving the lives, health, and well-being of newborns at risk for kidney disease.

AB - Introduction: Acute kidney injury (AKI) affects ~30% of hospitalized neonates. Critical to advancing our understanding of neonatal AKI is collaborative research among neonatologists and nephrologists. The Neonatal Kidney Collaborative (NKC) is an international, multidisciplinary group dedicated to investigating neonatal AKI. The AWAKEN study (Assessment of Worldwide Acute Kidney injury Epidemiology in Neonates) was designed to describe the epidemiology of neonatal AKI, validate the definition of neonatal AKI, identify primary risk factors for neonatal AKI, and investigate the contribution of fluid management to AKI events and short-term outcomes. Methods and analysis: The NKC was established with at least one pediatric nephrologist and neonatologist from 24 institutions in 4 countries (USA, Canada, Australia, and India). A Steering Committee and four subcommittees were created. The database subcommittee oversaw the development of the web-based database (MediData Rave™) that captured all NICU admissions from 1/1/14 to 3/31/14. Inclusion and exclusion criteria were applied to eliminate neonates with a low likelihood of AKI. Data collection included: (1) baseline demographic information; (2) daily physiologic parameters and care received during the first week of life; (3) weekly "snapshots"; (4) discharge information including growth parameters, final diagnoses, discharge medications, and need for renal replacement therapy; and (5) all serum creatinine values. Ethics and dissemination: AWAKEN was proposed as human subjects research. The study design allowed for a waiver of informed consent/parental permission. NKC investigators will disseminate data through peer-reviewed publications and educational conferences. Discussion: The purpose of this publication is to describe the formation of the NKC, the establishment of the AWAKEN cohort and database, future directions, and a few "lessons learned." The AWAKEN database includes ~325 unique variables and > 4 million discrete data points. AWAKEN will be the largest, most inclusive neonatal AKI study to date. In addition to validating the neonatal AKI definition and identifying risk factors for AKI, this study will uncover variations in practice patterns related to fluid provision, renal function monitoring, and involvement of pediatric nephrologists during hospitalization. The AWAKEN study will position the NKC to achieve the long-term goal of improving the lives, health, and well-being of newborns at risk for kidney disease.

KW - Acute renal failure

KW - AWAKEN

KW - Database

KW - KDIGO

KW - Neonate

KW - NKC

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