Assessment of Bone Perfusion with Contrast-Enhanced Magnetic Resonance Imaging

Jonathan H. Lee, Jonathan P. Dyke, Douglas Ballon, Deborah McK Ciombor, Glenn Tung, Roy K. Aaron

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Osteoarthritis and avascular necrosis are common clinical entities with unknown origins. Recently, vascular changes were implicated in the pathogenesis of both conditions. This article discusses the use of novel noninvasive imaging techniques as a means of assessing bone perfusion and quantifying differences seen in osteoarthritis and avascular necrosis. Review of our human data suggests that the MRI contrast dye is retained for longer periods of time, suggesting decreased perfusion out of regions of osteoarthritis and avascular necrosis. Use of such a noninvasive measure of assessing bone perfusion could be useful in the diagnosis, prevention, and treatment of not only osteoarthritis and avascular necrosis but also other entities that affect the musculoskeletal system.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalOrthopedic Clinics of North America
Volume40
Issue number2
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Osteoarthritis
Necrosis
Perfusion
Magnetic Resonance Imaging
Bone and Bones
Musculoskeletal System
Blood Vessels
Coloring Agents

Keywords

  • Animal model
  • Guinea pig
  • MRI
  • Osteoarthritis
  • Subchondral
  • Venous outflow occlusion

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Assessment of Bone Perfusion with Contrast-Enhanced Magnetic Resonance Imaging. / Lee, Jonathan H.; Dyke, Jonathan P.; Ballon, Douglas; Ciombor, Deborah McK; Tung, Glenn; Aaron, Roy K.

In: Orthopedic Clinics of North America, Vol. 40, No. 2, 04.2009, p. 249-257.

Research output: Contribution to journalReview article

Lee, Jonathan H. ; Dyke, Jonathan P. ; Ballon, Douglas ; Ciombor, Deborah McK ; Tung, Glenn ; Aaron, Roy K. / Assessment of Bone Perfusion with Contrast-Enhanced Magnetic Resonance Imaging. In: Orthopedic Clinics of North America. 2009 ; Vol. 40, No. 2. pp. 249-257.
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