Aspects of attention in rett syndrome

Susan A. Rose, Aleksandra Djukic, Jeffery J. Jankowski, Judith F. Feldman, Menachem Rimler

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background We sought to examine fundamental aspects of attention in children with Rett syndrome, a severely disabling neurodevelopmental disorder caused by spontaneous mutations in the X-linked MECP2 gene. To gauge their attention, we used eye tracking, which bypasses the profound impairments in expressive language and hand use in Rett syndrome. We report two aspects of attention - shifting and sustaining - basic abilities known to drive cognitive growth. Methods Two groups were compared: those with Rett syndrome (N = 20; 3-15 years) and a typically developing comparison group (N = 14; 3-16 years), using a task in which an attractive central stimulus was followed, after a short gap, by a dynamic target presented to one side. Time to shift to the target location (reactive and anticipatory saccades) and time fixating the target were assessed. Results Children with Rett syndrome were consistently slower to shift (largely because of fewer anticipations); their reactive saccades were also slower than those of typically developing children, but not significantly so. The Rett syndrome group spent considerable time looking at the target (over 75% of available time), although significantly less so than the typically developing group. Conclusions These findings indicate that children with Rett syndrome could maintain attention on a stimulus and orient relatively quickly to the appearance of a target in the visual field. However, they had difficulty in anticipating predictable events, a difficulty in endogenous attention that is likely to have deleterious implications for executive functioning.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalPediatric Neurology
Volume57
DOIs
StatePublished - Apr 1 2016

Fingerprint

Rett Syndrome
Saccades
X-Linked Genes
Aptitude
Visual Fields
Language
Hand
Mutation
Growth

Keywords

  • anticipation
  • executive attention
  • eye tracking
  • orienting
  • Rett syndrome
  • shifting attention
  • sustaining attention

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Rose, S. A., Djukic, A., Jankowski, J. J., Feldman, J. F., & Rimler, M. (2016). Aspects of attention in rett syndrome. Pediatric Neurology, 57, 22-28. https://doi.org/10.1016/j.pediatrneurol.2016.01.015

Aspects of attention in rett syndrome. / Rose, Susan A.; Djukic, Aleksandra; Jankowski, Jeffery J.; Feldman, Judith F.; Rimler, Menachem.

In: Pediatric Neurology, Vol. 57, 01.04.2016, p. 22-28.

Research output: Contribution to journalArticle

Rose, SA, Djukic, A, Jankowski, JJ, Feldman, JF & Rimler, M 2016, 'Aspects of attention in rett syndrome', Pediatric Neurology, vol. 57, pp. 22-28. https://doi.org/10.1016/j.pediatrneurol.2016.01.015
Rose, Susan A. ; Djukic, Aleksandra ; Jankowski, Jeffery J. ; Feldman, Judith F. ; Rimler, Menachem. / Aspects of attention in rett syndrome. In: Pediatric Neurology. 2016 ; Vol. 57. pp. 22-28.
@article{63b2fe25f64743d19e458590f99a5238,
title = "Aspects of attention in rett syndrome",
abstract = "Background We sought to examine fundamental aspects of attention in children with Rett syndrome, a severely disabling neurodevelopmental disorder caused by spontaneous mutations in the X-linked MECP2 gene. To gauge their attention, we used eye tracking, which bypasses the profound impairments in expressive language and hand use in Rett syndrome. We report two aspects of attention - shifting and sustaining - basic abilities known to drive cognitive growth. Methods Two groups were compared: those with Rett syndrome (N = 20; 3-15 years) and a typically developing comparison group (N = 14; 3-16 years), using a task in which an attractive central stimulus was followed, after a short gap, by a dynamic target presented to one side. Time to shift to the target location (reactive and anticipatory saccades) and time fixating the target were assessed. Results Children with Rett syndrome were consistently slower to shift (largely because of fewer anticipations); their reactive saccades were also slower than those of typically developing children, but not significantly so. The Rett syndrome group spent considerable time looking at the target (over 75{\%} of available time), although significantly less so than the typically developing group. Conclusions These findings indicate that children with Rett syndrome could maintain attention on a stimulus and orient relatively quickly to the appearance of a target in the visual field. However, they had difficulty in anticipating predictable events, a difficulty in endogenous attention that is likely to have deleterious implications for executive functioning.",
keywords = "anticipation, executive attention, eye tracking, orienting, Rett syndrome, shifting attention, sustaining attention",
author = "Rose, {Susan A.} and Aleksandra Djukic and Jankowski, {Jeffery J.} and Feldman, {Judith F.} and Menachem Rimler",
year = "2016",
month = "4",
day = "1",
doi = "10.1016/j.pediatrneurol.2016.01.015",
language = "English (US)",
volume = "57",
pages = "22--28",
journal = "Pediatric Neurology",
issn = "0887-8994",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Aspects of attention in rett syndrome

AU - Rose, Susan A.

AU - Djukic, Aleksandra

AU - Jankowski, Jeffery J.

AU - Feldman, Judith F.

AU - Rimler, Menachem

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background We sought to examine fundamental aspects of attention in children with Rett syndrome, a severely disabling neurodevelopmental disorder caused by spontaneous mutations in the X-linked MECP2 gene. To gauge their attention, we used eye tracking, which bypasses the profound impairments in expressive language and hand use in Rett syndrome. We report two aspects of attention - shifting and sustaining - basic abilities known to drive cognitive growth. Methods Two groups were compared: those with Rett syndrome (N = 20; 3-15 years) and a typically developing comparison group (N = 14; 3-16 years), using a task in which an attractive central stimulus was followed, after a short gap, by a dynamic target presented to one side. Time to shift to the target location (reactive and anticipatory saccades) and time fixating the target were assessed. Results Children with Rett syndrome were consistently slower to shift (largely because of fewer anticipations); their reactive saccades were also slower than those of typically developing children, but not significantly so. The Rett syndrome group spent considerable time looking at the target (over 75% of available time), although significantly less so than the typically developing group. Conclusions These findings indicate that children with Rett syndrome could maintain attention on a stimulus and orient relatively quickly to the appearance of a target in the visual field. However, they had difficulty in anticipating predictable events, a difficulty in endogenous attention that is likely to have deleterious implications for executive functioning.

AB - Background We sought to examine fundamental aspects of attention in children with Rett syndrome, a severely disabling neurodevelopmental disorder caused by spontaneous mutations in the X-linked MECP2 gene. To gauge their attention, we used eye tracking, which bypasses the profound impairments in expressive language and hand use in Rett syndrome. We report two aspects of attention - shifting and sustaining - basic abilities known to drive cognitive growth. Methods Two groups were compared: those with Rett syndrome (N = 20; 3-15 years) and a typically developing comparison group (N = 14; 3-16 years), using a task in which an attractive central stimulus was followed, after a short gap, by a dynamic target presented to one side. Time to shift to the target location (reactive and anticipatory saccades) and time fixating the target were assessed. Results Children with Rett syndrome were consistently slower to shift (largely because of fewer anticipations); their reactive saccades were also slower than those of typically developing children, but not significantly so. The Rett syndrome group spent considerable time looking at the target (over 75% of available time), although significantly less so than the typically developing group. Conclusions These findings indicate that children with Rett syndrome could maintain attention on a stimulus and orient relatively quickly to the appearance of a target in the visual field. However, they had difficulty in anticipating predictable events, a difficulty in endogenous attention that is likely to have deleterious implications for executive functioning.

KW - anticipation

KW - executive attention

KW - eye tracking

KW - orienting

KW - Rett syndrome

KW - shifting attention

KW - sustaining attention

UR - http://www.scopus.com/inward/record.url?scp=84961200666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961200666&partnerID=8YFLogxK

U2 - 10.1016/j.pediatrneurol.2016.01.015

DO - 10.1016/j.pediatrneurol.2016.01.015

M3 - Article

VL - 57

SP - 22

EP - 28

JO - Pediatric Neurology

JF - Pediatric Neurology

SN - 0887-8994

ER -