Ashkenazi Jewish Screening in the Twenty-first Century

Susan D. Klugman, Susan J. Gross

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Ashkenazi Jewish genetic screening has expanded significantly in the past 4 decades. Individuals of Eastern European (Ashkenazi) Jewish (AJ) descent are at increased risk of having offspring with particular genetic diseases that have significant morbidity and mortality. In addition, there are some disorders, such as cystic fibrosis, for which northern European Caucasians are at comparable risk with those of an AJ background. Carrier screening for many of these Jewish genetic disorders has become standard of care. As technology advances, so does the number of disorders for which screening is available. Thus, we need to continue to be cognizant of informed consent, test sensitivity, confidentiality, prenatal diagnosis, preimplantation genetic screening, and public health concerns regarding testing.

Original languageEnglish (US)
Pages (from-to)37-46
Number of pages10
JournalObstetrics and Gynecology Clinics of North America
Volume37
Issue number1
DOIs
StatePublished - Mar 2010

Fingerprint

Inborn Genetic Diseases
Genetic Testing
Preimplantation Diagnosis
Confidentiality
Standard of Care
Informed Consent
Prenatal Diagnosis
Cystic Fibrosis
Public Health
Technology
Morbidity
Mortality

Keywords

  • Ashkenazi Jewish genetic screening
  • Carrier screening
  • Jewish genetic disorders

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Ashkenazi Jewish Screening in the Twenty-first Century. / Klugman, Susan D.; Gross, Susan J.

In: Obstetrics and Gynecology Clinics of North America, Vol. 37, No. 1, 03.2010, p. 37-46.

Research output: Contribution to journalArticle

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