TY - JOUR
T1 - Arousal and cardiorespiratory responses to hypoxia in Prader-Willi syndrome
AU - Arens, Raanan
AU - Gozal, David
AU - Burrell, Brian C.
AU - Bailey, Sandra L.
AU - Bautista, Daisy B.
AU - Keens, Thomas C.
AU - Davidson Ward, Sally L.
PY - 1996
Y1 - 1996
N2 - Ventilatory responses to peripheral chemoreceptor stimuli are absent in patients with Prader-Willi syndrome (PWS) during wakefulness. Because arousal from sleep after rapidly developing hypoxia may require intact peripheral chemoreceptor function, we hypothesized that blunted hypoxic arousal responses during sleep Stage 3/4 would be present in PWS. Thirteen patients with PWS (mean age, 23.4 ± 3.7 ± SEM yr; 46% male; body mass index [BMI], 28.9 ± 1.6 kg/m2) and 11 matched control subjects (mean age 28.0 ± 5.4 yr; 54% male; BMI, 28.8 ± 3.1 kg/m2) were studied. An abrupt decrease in inspired O2 tension to 80 mm Hg was introduced until arousal occurred or for a maximum of 3 min. One of the 13 patients with PWS and seven of the 11 control subjects were aroused by the hypoxic challenge (p < 0.02). During hypoxia, heart rate increased by 9 ± 2% in the PWS group versus 22 ± 4% in the control group (p < 0.005). Respiratory rate did not change in the PWS group (4 ± 2%; p = NS), but it increased by 13 ± 2% in the control group (p < 0.02). We conclude that abnormal arousal and cardiorespiratory responses to hypoxia are frequent in PWS. We postulate that intact peripheral chemoreceptor function is an important component underlying arousal mechanisms to rapidly developing hypoxia during sleep.
AB - Ventilatory responses to peripheral chemoreceptor stimuli are absent in patients with Prader-Willi syndrome (PWS) during wakefulness. Because arousal from sleep after rapidly developing hypoxia may require intact peripheral chemoreceptor function, we hypothesized that blunted hypoxic arousal responses during sleep Stage 3/4 would be present in PWS. Thirteen patients with PWS (mean age, 23.4 ± 3.7 ± SEM yr; 46% male; body mass index [BMI], 28.9 ± 1.6 kg/m2) and 11 matched control subjects (mean age 28.0 ± 5.4 yr; 54% male; BMI, 28.8 ± 3.1 kg/m2) were studied. An abrupt decrease in inspired O2 tension to 80 mm Hg was introduced until arousal occurred or for a maximum of 3 min. One of the 13 patients with PWS and seven of the 11 control subjects were aroused by the hypoxic challenge (p < 0.02). During hypoxia, heart rate increased by 9 ± 2% in the PWS group versus 22 ± 4% in the control group (p < 0.005). Respiratory rate did not change in the PWS group (4 ± 2%; p = NS), but it increased by 13 ± 2% in the control group (p < 0.02). We conclude that abnormal arousal and cardiorespiratory responses to hypoxia are frequent in PWS. We postulate that intact peripheral chemoreceptor function is an important component underlying arousal mechanisms to rapidly developing hypoxia during sleep.
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U2 - 10.1164/ajrccm.153.1.8542130
DO - 10.1164/ajrccm.153.1.8542130
M3 - Article
C2 - 8542130
AN - SCOPUS:0030028446
SN - 1073-449X
VL - 153
SP - 283
EP - 287
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 1
ER -