TY - JOUR
T1 - Are antioxidant levels measured immediately postoperatively an indicator of magnitude of injury?
AU - Morris, Don M.
AU - Smith, Harriet O.
AU - Liu, Wei
AU - Genesen, Mark C.
AU - Vander Jagt, Dorothy H.
AU - Glew, Robert H.
AU - Fry, Donald E.
PY - 2000
Y1 - 2000
N2 - Background: Little is known about the changes that occur in antioxidant levels in response to surgical trauma. The antioxidant system may influence recovery and healing after operation. Miller et al described a reliable assay for total antioxidant capacity of serum. We studied changes in antioxidant levels secondary to operation using this assay. Methods: Twenty-seven patients were studied: 14 abdominal and 13 breast cancer operations. Initial blood samples were obtained when starting the preoperative intravenous line, the second in the recovery room, and every 6 hours thereafter. Results: Levels did not correlate with diagnosis, extent of operation, age, body mass index, or complications. Differences between preoperative and postoperative values in the down and up groups were significant at P = 0.002 and P = 0.023, respectively. Differences in initial levels between the down and up groups were significant at P = 0.005. Levels 12 hours after operation were stable. Conclusions: Rapid return to a baseline of approximately 1 μmole/L, regardless of the direction of initial response, supports the concept of a set point for regulation of serum's antioxidant capacity. (C) 2001 by Excerpta Medica, Inc.
AB - Background: Little is known about the changes that occur in antioxidant levels in response to surgical trauma. The antioxidant system may influence recovery and healing after operation. Miller et al described a reliable assay for total antioxidant capacity of serum. We studied changes in antioxidant levels secondary to operation using this assay. Methods: Twenty-seven patients were studied: 14 abdominal and 13 breast cancer operations. Initial blood samples were obtained when starting the preoperative intravenous line, the second in the recovery room, and every 6 hours thereafter. Results: Levels did not correlate with diagnosis, extent of operation, age, body mass index, or complications. Differences between preoperative and postoperative values in the down and up groups were significant at P = 0.002 and P = 0.023, respectively. Differences in initial levels between the down and up groups were significant at P = 0.005. Levels 12 hours after operation were stable. Conclusions: Rapid return to a baseline of approximately 1 μmole/L, regardless of the direction of initial response, supports the concept of a set point for regulation of serum's antioxidant capacity. (C) 2001 by Excerpta Medica, Inc.
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U2 - 10.1016/S0002-9610(00)00475-X
DO - 10.1016/S0002-9610(00)00475-X
M3 - Article
C2 - 11084132
AN - SCOPUS:0033730555
SN - 0002-9610
VL - 180
SP - 212
EP - 216
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 3
ER -