Aptamers and aptamer targeted delivery

Amy C. Yan, Matthew Levy

Research output: Contribution to journalReview article

61 Scopus citations

Abstract

When aptamers first emerged almost two decades ago, most were RNA species that bound and tagged or inhibited simple target ligands. Very soon after, the 'selectionologists' developing aptamer technology quickly realized more potential for the aptamer. In recent years, advances in aptamer techniques have enabled the use of aptamers as small molecule inhibitors, diagnostic tools and even therapeutics. Aptamers are now being employed in novel applications. We review, herein, some of the recent and exciting applications of aptamers in cell-specific recognition and delivery.

Original languageEnglish (US)
Pages (from-to)316-320
Number of pages5
JournalRNA biology
Volume6
Issue number3
DOIs
StatePublished - 2009

Keywords

  • Aptamers
  • In vitro selection
  • SELEX
  • Targeted delivery
  • siRNA delivery

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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