Apoptosis in polycystic kidney disease

Research output: Contribution to journalReview article

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Abstract

Apoptosis is the process of programmed cell death. It is a ubiquitous, controlled process consuming cellular energy and designed to avoid cytokine release despite activation of local immune cells, which clear the cell fragments. The process occurs during organ development and in maintenance of homeostasis. Abnormalities in any step of the apoptotic process are associated with autoimmune diseases and malignancies. Polycystic kidney disease (PKD) is the most common inherited kidney disease leading to end-stage renal disease (ESRD). Cyst formation requires multiple mechanisms and apoptosis is considered one of them. Abnormalities in apoptotic processes have been described in various murine and rodent models of PKD as well as in human PKD kidneys. The purpose of this review is to outline the role of apoptosis in progression of PKD as well as to describe the mechanisms involved.

Original languageEnglish (US)
Pages (from-to)1272-1280
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1812
Issue number10
DOIs
StatePublished - Oct 1 2011

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Keywords

  • Apoptosis
  • Caspases
  • Cell Cycle
  • Polycystic kidney disease

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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