Apoptosis in polycystic kidney disease

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Apoptosis is the process of programmed cell death. It is a ubiquitous, controlled process consuming cellular energy and designed to avoid cytokine release despite activation of local immune cells, which clear the cell fragments. The process occurs during organ development and in maintenance of homeostasis. Abnormalities in any step of the apoptotic process are associated with autoimmune diseases and malignancies. Polycystic kidney disease (PKD) is the most common inherited kidney disease leading to end-stage renal disease (ESRD). Cyst formation requires multiple mechanisms and apoptosis is considered one of them. Abnormalities in apoptotic processes have been described in various murine and rodent models of PKD as well as in human PKD kidneys. The purpose of this review is to outline the role of apoptosis in progression of PKD as well as to describe the mechanisms involved.

Original languageEnglish (US)
Pages (from-to)1272-1280
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1812
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Polycystic Kidney Diseases
Apoptosis
Kidney Diseases
Autoimmune Diseases
Chronic Kidney Failure
Cysts
Rodentia
Homeostasis
Cell Death
Maintenance
Cytokines
Kidney
Neoplasms

Keywords

  • Apoptosis
  • Caspases
  • Cell Cycle
  • Polycystic kidney disease

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Apoptosis in polycystic kidney disease. / Goilav, Beatrice.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1812, No. 10, 10.2011, p. 1272-1280.

Research output: Contribution to journalArticle

@article{ed324237d8964c64a78fa5318d177242,
title = "Apoptosis in polycystic kidney disease",
abstract = "Apoptosis is the process of programmed cell death. It is a ubiquitous, controlled process consuming cellular energy and designed to avoid cytokine release despite activation of local immune cells, which clear the cell fragments. The process occurs during organ development and in maintenance of homeostasis. Abnormalities in any step of the apoptotic process are associated with autoimmune diseases and malignancies. Polycystic kidney disease (PKD) is the most common inherited kidney disease leading to end-stage renal disease (ESRD). Cyst formation requires multiple mechanisms and apoptosis is considered one of them. Abnormalities in apoptotic processes have been described in various murine and rodent models of PKD as well as in human PKD kidneys. The purpose of this review is to outline the role of apoptosis in progression of PKD as well as to describe the mechanisms involved.",
keywords = "Apoptosis, Caspases, Cell Cycle, Polycystic kidney disease",
author = "Beatrice Goilav",
year = "2011",
month = "10",
doi = "10.1016/j.bbadis.2011.01.006",
language = "English (US)",
volume = "1812",
pages = "1272--1280",
journal = "Biochimica et Biophysica Acta - Molecular Basis of Disease",
issn = "0925-4439",
publisher = "Elsevier",
number = "10",

}

TY - JOUR

T1 - Apoptosis in polycystic kidney disease

AU - Goilav, Beatrice

PY - 2011/10

Y1 - 2011/10

N2 - Apoptosis is the process of programmed cell death. It is a ubiquitous, controlled process consuming cellular energy and designed to avoid cytokine release despite activation of local immune cells, which clear the cell fragments. The process occurs during organ development and in maintenance of homeostasis. Abnormalities in any step of the apoptotic process are associated with autoimmune diseases and malignancies. Polycystic kidney disease (PKD) is the most common inherited kidney disease leading to end-stage renal disease (ESRD). Cyst formation requires multiple mechanisms and apoptosis is considered one of them. Abnormalities in apoptotic processes have been described in various murine and rodent models of PKD as well as in human PKD kidneys. The purpose of this review is to outline the role of apoptosis in progression of PKD as well as to describe the mechanisms involved.

AB - Apoptosis is the process of programmed cell death. It is a ubiquitous, controlled process consuming cellular energy and designed to avoid cytokine release despite activation of local immune cells, which clear the cell fragments. The process occurs during organ development and in maintenance of homeostasis. Abnormalities in any step of the apoptotic process are associated with autoimmune diseases and malignancies. Polycystic kidney disease (PKD) is the most common inherited kidney disease leading to end-stage renal disease (ESRD). Cyst formation requires multiple mechanisms and apoptosis is considered one of them. Abnormalities in apoptotic processes have been described in various murine and rodent models of PKD as well as in human PKD kidneys. The purpose of this review is to outline the role of apoptosis in progression of PKD as well as to describe the mechanisms involved.

KW - Apoptosis

KW - Caspases

KW - Cell Cycle

KW - Polycystic kidney disease

UR - http://www.scopus.com/inward/record.url?scp=80052259229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052259229&partnerID=8YFLogxK

U2 - 10.1016/j.bbadis.2011.01.006

DO - 10.1016/j.bbadis.2011.01.006

M3 - Article

VL - 1812

SP - 1272

EP - 1280

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

SN - 0925-4439

IS - 10

ER -