Anxiety-and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats

M. Ates, A. Dayi, M. Kiray, A. R. Sisman, S. Agilkaya, I. Aksu, B. Baykara, Erkan Buyuk, C. Cetinkaya, S. Cingoz, Nazan Uysal

Research output: Contribution to journalArticle

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Abstract

Anxiety and depression are common in diabetics. Diabetes also may cause reduced leptin levels in the blood. We investigated the relation between diabetes induced anxiety-and depression-like behavior, and leptin and leptin receptor expression levels in diabetic rats. The anxiety-and depression-like behaviors of rats were assessed 4 weeks after intraperitoneal injection of streptozotocin. Diabetic rats exhibited greater anxiety-like behavior; they spent more time in closed branches of the elevated plus maze test and less time in the center cells of the open field arena. Increased depression-like behavior was observed in diabetic rats using the Porsolt swim test. Prefrontal cortex (PFC), blood leptin levels and PFC neuron numbers were decreased, and leptin receptor expression and apoptosis were increased in diabetic rats. Blood corticosterone levels also were increased in diabetic rats. These results indicate that reduction of leptin up-regulates leptin receptor expression and may affect PFC neurons, which eventually triggers anxiety-and depression-like behaviors in diabetic rats.

Original languageEnglish (US)
Pages (from-to)161-171
Number of pages11
JournalBiotechnic and Histochemistry
Volume89
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Leptin Receptors
Streptozocin
Leptin
Prefrontal Cortex
Anxiety
Depression
Neurons
Corticosterone
Intraperitoneal Injections
Up-Regulation
Apoptosis

Keywords

  • Anxiety
  • Depression
  • Diabetes mellitus
  • Leptin
  • Prefrontal cortex
  • Receptors

ASJC Scopus subject areas

  • Histology
  • Medical Laboratory Technology
  • Medicine(all)

Cite this

Anxiety-and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats. / Ates, M.; Dayi, A.; Kiray, M.; Sisman, A. R.; Agilkaya, S.; Aksu, I.; Baykara, B.; Buyuk, Erkan; Cetinkaya, C.; Cingoz, S.; Uysal, Nazan.

In: Biotechnic and Histochemistry, Vol. 89, No. 3, 2014, p. 161-171.

Research output: Contribution to journalArticle

Ates, M, Dayi, A, Kiray, M, Sisman, AR, Agilkaya, S, Aksu, I, Baykara, B, Buyuk, E, Cetinkaya, C, Cingoz, S & Uysal, N 2014, 'Anxiety-and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats', Biotechnic and Histochemistry, vol. 89, no. 3, pp. 161-171. https://doi.org/10.3109/10520295.2013.825319
Ates, M. ; Dayi, A. ; Kiray, M. ; Sisman, A. R. ; Agilkaya, S. ; Aksu, I. ; Baykara, B. ; Buyuk, Erkan ; Cetinkaya, C. ; Cingoz, S. ; Uysal, Nazan. / Anxiety-and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats. In: Biotechnic and Histochemistry. 2014 ; Vol. 89, No. 3. pp. 161-171.
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