Antitumor Activity of Vinflunine: Effector Pathways and Potential for Synergies

Diane Braguer, Jean Marc Barret, Hayley M. McDaid, Anna Kruczynski

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Vinflunine is an innovative microtubule inhibitor of the vinca alkaloid class with distinct tubulin-binding properties. Preclinical evaluation of this novel microtubule inhibitor has shown superior antitumor activity against a broad spectrum of tumor types in vitro and in vivo, in comparison with other vinca alkaloids. The antitumor effect of vinflunine is largely attributable to its modulation of microtubule dynamics, and is mediated by its ability to induce apoptosis in target cells. At non-cytotoxic concentrations, vinflunine also exerts antiangiogenic and antivascular activity. The favorable preclinical profile of vinflunine, in addition to its synergism with a variety of other therapeutic modalities, justifies further clinical development of this compound.

Original languageEnglish (US)
JournalSeminars in Oncology
Volume35
Issue numberSUPPL 3
DOIs
StatePublished - Jun 2008

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Microtubules
Vinca Alkaloids
Tubulin
Apoptosis
vinflunine
Neoplasms
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Oncology

Cite this

Antitumor Activity of Vinflunine : Effector Pathways and Potential for Synergies. / Braguer, Diane; Barret, Jean Marc; McDaid, Hayley M.; Kruczynski, Anna.

In: Seminars in Oncology, Vol. 35, No. SUPPL 3, 06.2008.

Research output: Contribution to journalArticle

Braguer, Diane ; Barret, Jean Marc ; McDaid, Hayley M. ; Kruczynski, Anna. / Antitumor Activity of Vinflunine : Effector Pathways and Potential for Synergies. In: Seminars in Oncology. 2008 ; Vol. 35, No. SUPPL 3.
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