Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women

Michelle M. Estrella, Alison G. Abraham, Yuezhou Jing, Rulan S. Parekh, Phyllis C. Tien, Dan Merenstein, Celeste Leigh Pearce, Kathryn Anastos, Mardge H. Cohen, Jack A. Dehovitz, Stephen J. Gange

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Natural history studies suggest increased risk for kidney function decline with HIV infection, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV infection treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. HIV-infected women initiating HAART with (n=105) or without (n=373) tenofovir (TDF) were matched to HIV-uninfected women on calendar and length of follow-up, age, systolic blood pressure, hepatitis C antibody serostatus, and diabetes history. Linear mixed models were used to evaluate differences in annual estimated glomerular filtration rate (eGFR). Person-visits were 4,741 and 11,512 for the TDF-treated and non-TDF-treated analyses, respectively. Mean baseline eGFRs were higher among women initiated on TDF-containing HAART and lower among those on TDF-sparing HAART compared to their respective HIV-uninfected matches (p<0.05 for both). HIV-infected women had annual rates of eGFR changes similar to HIV-uninfected matches (p-interaction >0.05 for both). Adjusting for baseline eGFR, mean eGFRs at 1 and 3 years of follow-up among women initiated on TDF-containing HAART were lower than their uninfected matches (-4.98 and-4.26 ml/min/1.73 m2, respectively; p<0.05 for both). Mean eGFR of women initiated on TDF-sparing HAART was lower versus uninfected matches at 5 years (-2.19 ml/min/1.73 m2, p=0.03). HAART-treated HIV-infected women had lower mean eGFRs at follow-up but experienced rates of annual eGFR decline similar to HIV-uninfected women. Tenofovir use in HIV-infected women with normal kidney function did not accelerate long-term kidney function decline relative to HIV-uninfected women.

Original languageEnglish (US)
Pages (from-to)755-760
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume29
Issue number5
DOIs
StatePublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women'. Together they form a unique fingerprint.

  • Cite this

    Estrella, M. M., Abraham, A. G., Jing, Y., Parekh, R. S., Tien, P. C., Merenstein, D., Pearce, C. L., Anastos, K., Cohen, M. H., Dehovitz, J. A., & Gange, S. J. (2013). Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women. AIDS Research and Human Retroviruses, 29(5), 755-760. https://doi.org/10.1089/aid.2012.0248