To the Editor: The study of Gralla et al. (October 15 issue*) is of great interest and is scientific. However, one can no longer consider it ethical to use placebos in research on antiemetics; withholding an antiemetic agent in such circumstances must make a difference in overall mortality, since there will be a loss of compliance with the chemotherapeutic regimen. The increase in morbidity cannot be measured directly, but it must be considerable. Future studies should be directed at comparing antiemetic agents only.
ASJC Scopus subject areas